• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Madecassoside

Madecassoside

Product ID M0113
Cas No. 34540-22-2
Purity ≥90%
Product Unit SizeCostQuantityStock
25 mg $136.70 In stock
100 mg $300.60 In stock
250 mg $546.90 In stock
1 g $1,640.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Madecassoside is a triterpenoid found in Centella that exhibits anti-inflammatory, antioxidative, anti-fibrotic, neuroprotective, and cardioprotective activities. In animal models of cerebral ischemia/reperfusion, madecassoside downregulates expression of malondialdehyde, NO, and pro-inflammatory cytokines, prevents apoptosis, decreases infarct size, and attenuates cognitive deficits. Madecassoside protects neurons against amyloid-β (Aβ)-induced inflammation and autophagy; it also shows potential benefit in animal models of Parkinson’s disease. Additionally, madecassoside downregulates expression of α-smooth muscle actin and TGF-β1, attenuates phosphorylation of Smad2/3, decreases myeloperoxidase activity and malondialdehyde levels, and increases superoxide dismutase and glutathione levels, ameliorating pulmonary fibrosis. This compound also decreases infarct size, lowers levels of lactate dehydrogenase, malondialdehyde, and creatine kinase, and suppresses apoptosis, providing protection in myocardial ischemia/reperfusion models.

Product Info

Cas No.

34540-22-2

Purity

≥90%

Formula

C48H78O20

Formula Wt.

975.12

IUPAC Name

[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate

Solubility

Soluble in water (10 mg/mL).

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M0113 MSDS PDF

Info Sheet

M0113 Info Sheet PDF

References

Luo Y, Yang YP, Liu J, et al. Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. Brain Res. 2014 May 27;1565:37-47. PMID: 24735651.

Du B, Zhang Z, Li N. Madecassoside prevents Aβ(25-35)-induced inflammatory responses and autophagy in neuronal cells through the class III PI3K/Beclin-1/Bcl-2 pathway. Int Immunopharmacol. 2014 May;20(1):221-8. PMID: 24631516.

Lu GX, Bian DF, Ji Y, et al. Madecassoside Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice by Downregulating Collagen Deposition. Phytother Res. 2014 Jan 23. [Epub ahead of print]. PMID: 24458872.

Bian GX, Li GG, Yang Y, et al. Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat. Biol Pharm Bull. 2008 Mar;31(3):458-63. PMID: 18310910.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • J889290

    JWH 133

    Cannabinoid receptor 2 selective agonist.

    ≥95%
  • P3313

    Pidotimod

    Immunostimulator, adjuvant.

    ≥98%
  • L589940

    LOXO-101

    Inhibitor of tropomyosin kinase receptors TRKA,...

    ≥99%
  • G4484

    Glucagon-like Peptide II, rat

    Endogenous peptide hormone, involved in intesti...

    ≥95%
  • B1870

    Berberine Chloride

    Isoquinoline alkaloid found in various plant so...

    ≥97%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • B6935

    Brivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • G1849

    Gemifloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • N9874

    Nystatin

    Polyene macrolide, induces pore formation in fu...

    4400u/mg
  • A6818

    Arenobufagin

    Bufanolide steroid found in Bufo arenarum;VEGFR...

    ≥98%
  • T0095

    Baccatin III

    Diterpene found in Taxus, used to synthesize ta...

    ≥98%
  • C0269

    β-Carotene

    Red-orange terpene pigment found in various pla...

    ≥98%
  • S6800

    SR1001

    RORα/γ inverse agonist.

    ≥99%
  • Q8135

    Quinestrol

    Synthetic steroid hormone, estrogen analog, use...

    ≥98%
  • T1968

    Terpinen-4-ol

    Monoterpene found in various plant sources.

    ≥98%
  • A0833

    Acipimox

    Niacin derivative.

    ≥98%
  • E7310

    Esculin

    Coumarin glucoside found in Aesculus, Daphne, a...

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • F4681

    Flumazenil

    GABA-A antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only