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Madecassoside

Madecassoside

Product ID M0113
Cas No. 34540-22-2
Purity ≥90%
Product Unit SizeCostQuantityStock
25 mg $136.70 In stock
100 mg $300.60 In stock
250 mg $546.90 In stock
1 g $1,640.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Madecassoside is a triterpenoid found in Centella that exhibits anti-inflammatory, antioxidative, anti-fibrotic, neuroprotective, and cardioprotective activities. In animal models of cerebral ischemia/reperfusion, madecassoside downregulates expression of malondialdehyde, NO, and pro-inflammatory cytokines, prevents apoptosis, decreases infarct size, and attenuates cognitive deficits. Madecassoside protects neurons against amyloid-β (Aβ)-induced inflammation and autophagy; it also shows potential benefit in animal models of Parkinson’s disease. Additionally, madecassoside downregulates expression of α-smooth muscle actin and TGF-β1, attenuates phosphorylation of Smad2/3, decreases myeloperoxidase activity and malondialdehyde levels, and increases superoxide dismutase and glutathione levels, ameliorating pulmonary fibrosis. This compound also decreases infarct size, lowers levels of lactate dehydrogenase, malondialdehyde, and creatine kinase, and suppresses apoptosis, providing protection in myocardial ischemia/reperfusion models.

Product Info

Cas No.

34540-22-2

Purity

≥90%

Formula

C48H78O20

Formula Wt.

975.12

IUPAC Name

[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate

Solubility

Soluble in water (10 mg/mL).

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M0113 MSDS PDF

Info Sheet

M0113 Info Sheet PDF

References

Luo Y, Yang YP, Liu J, et al. Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. Brain Res. 2014 May 27;1565:37-47. PMID: 24735651.

Du B, Zhang Z, Li N. Madecassoside prevents Aβ(25-35)-induced inflammatory responses and autophagy in neuronal cells through the class III PI3K/Beclin-1/Bcl-2 pathway. Int Immunopharmacol. 2014 May;20(1):221-8. PMID: 24631516.

Lu GX, Bian DF, Ji Y, et al. Madecassoside Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice by Downregulating Collagen Deposition. Phytother Res. 2014 Jan 23. [Epub ahead of print]. PMID: 24458872.

Bian GX, Li GG, Yang Y, et al. Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat. Biol Pharm Bull. 2008 Mar;31(3):458-63. PMID: 18310910.

Custom Order

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