Description
Men 10376 is a peptide antagonist at neurokinin-2 (NK2) receptors. Men 10376 decreases stretch-activated contractility in airway smooth muscle tissue ex vivo and inhibits OVA-induced bronchoconstriction in vivo.
Product Unit Size | Cost | Quantity | Stock |
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Men 10376 is a peptide antagonist at neurokinin-2 (NK2) receptors. Men 10376 decreases stretch-activated contractility in airway smooth muscle tissue ex vivo and inhibits OVA-induced bronchoconstriction in vivo.
Cas No. | 135306-85-3 |
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Purity | ≥95% |
Formula | C57H68N12O10 |
Formula Wt. | 1081.25 |
IUPAC Name | 3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid |
Synonym | Neurokinin A(4-10), tyr(5)-trp(6,8,9)-lys(10)- |
Solubility | Soluble in acetic acid. |
Appearance | White to off white powder |
Store Temp | -20°C |
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Ship Temp | Ambient |
MSDS | |
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Info Sheet |
Hernandez JM, Cox G, Janssen LJ. Involvement of the neurokinin-2 receptor in airway smooth muscle stretch-activated contractions assessed in perfused intact bovine bronchial segments. J Pharmacol Exp Ther. 2008 Nov;327(2):503-10. PMID: 18719290.
Krishnakumar S, Holmes EP, Moore RM, et al. Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors. Auton Autacoid Pharmacol. 2002 Aug;22(4):215-24. PMID: 12656947.
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