Description
Men 10376 is a peptide antagonist at neurokinin-2 (NK2) receptors. Men 10376 decreases stretch-activated contractility in airway smooth muscle tissue ex vivo and inhibits OVA-induced bronchoconstriction in vivo.
Men 10376
Product ID M1752
Cas No. 135306-85-3
Purity ≥95%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 135306-85-3 |
|---|---|
| Purity | ≥95% |
| Formula | C57H68N12O10 |
| Formula Wt. | 1081.25 |
| IUPAC Name | 3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid |
| Synonym | Neurokinin A(4-10), tyr(5)-trp(6,8,9)-lys(10)- |
| Solubility | Soluble in acetic acid. |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Hernandez JM, Cox G, Janssen LJ. Involvement of the neurokinin-2 receptor in airway smooth muscle stretch-activated contractions assessed in perfused intact bovine bronchial segments. J Pharmacol Exp Ther. 2008 Nov;327(2):503-10. PMID: 18719290.
Krishnakumar S, Holmes EP, Moore RM, et al. Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors. Auton Autacoid Pharmacol. 2002 Aug;22(4):215-24. PMID: 12656947.