• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
MG-132

MG-132

Product ID M2400
Cas No. 133407-82-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $136.70 In stock
25 mg $519.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MG-132 is a proteasome inhibitor that exhibits anti-fibrotic, anti-inflammatory, and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive pulmonary disorder (COPD) by preventing degradation of IκB and activation of NF-κB. In other animal models, this compound delays progression of osteoarthritis by inhibiting inflammation in cartilage and synovial tissue.

Product Info

Cas No.

133407-82-6

Purity

≥98%

Formula

C26H41N3O5

Formula Wt.

475.62

IUPAC Name

benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

Synonym

MG-132

Solubility

DMSO 90 mg/mL (189.22 mM) Ethanol 25 mg/mL (52.56 mM) Water Insoluble

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M2400 MSDS PDF

Info Sheet

M2400 Info Sheet PDF

References

Zhu B, Jin Y, Han L, et al. Proteasome inhibitor inhibits proliferation and induces apoptosis in renal interstitial fibroblasts. Pharmacol Rep. 2013;65(5):1357-65. PMID: 24399732.

Ma BM, Liu ZH, Liang ZK, et al. The proteasome inhibitor MG132 attenuates skeletal muscle atrophy in a rat model of chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2013 Jun;36(6):441-6. PMID: 24103208.

Quan R, Huang Z, Yue Z, et al. Effects of a proteasome inhibitor on the NF-κB signalling pathway in experimental osteoarthritis. Scand J Rheumatol. 2013;42(5):400-7. PMID: 23826657.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6232

    (−)-Epicatechin Gallate

    Flavanol originally found in Camilla (green tea...

    ≥98%
  • E6234

    Epigallocatechin Gallate

    Flavanol found in Camilla (green tea); AhR ant...

    ≥98%
  • C8070

    Curcumin, high purity

    Active compound found in turmeric; MST1 activat...

    ≥98%
  • C3352

    Cinacalcet Hydrochloride

    Ca2+-sensing receptor agonist.

    ≥99%
  • B6957

    Bromhexine Hydrochloride

    Synthetic derivative of vasicine, mucolytic.

    ≥98%
  • M1877

    Methylprednisolone

    Synthetic steroid; glucocorticoid agonist.

    ≥96%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • S2792

    SGX-523

    MET inhibitor.

    ≥98%
  • D3212

    2′,3′-Dideoxycytidine

    Pyrimidine nucleoside (cytidine) analog; DNA ch...

    ≥98%
  • C6132

    CPI-203

    Triazolothienodiazepine, JQ-1 derivative; BRD i...

    ≥98%
  • O4672

    Olsalazine Sodium

    5-Aminosalicylate prodrug, NSAID; COX-1/2 inhib...

    ≥98%
  • C2949

    Chlorpheniramine Maleate

    Alkylamine; histamine H1 antagonist, SERT and N...

    ≥98%
  • P3463

    Piperacillin Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • P0278

    Patulin

    Mycotoxin produced by Penicillum and Aspergillu...

    ≥98%
  • D5794

    Doxorubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase II ...
    ≥98%
  • A4606

    Albendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥95%
  • F4400

    Flag Peptide

    Peptide, used to tag proteins for affinity chro...

    ≥95%
  • G337543

    Ginsenoside CK

    Major metabolite of ginsenosides Rb1, Rb2, Rc, ...

    ≥98%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • R1627

    Regorafenib Anhydrous

    Multikinase inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only