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MG-132

MG-132

Product ID M2400
Cas No. 133407-82-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $136.70 In stock
25 mg $519.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MG-132 is a proteasome inhibitor that exhibits anti-fibrotic, anti-inflammatory, and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive pulmonary disorder (COPD) by preventing degradation of IκB and activation of NF-κB. In other animal models, this compound delays progression of osteoarthritis by inhibiting inflammation in cartilage and synovial tissue.

Product Info

Cas No.

133407-82-6

Purity

≥98%

Formula

C26H41N3O5

Formula Wt.

475.62

IUPAC Name

benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

Synonym

MG-132

Solubility

DMSO 90 mg/mL (189.22 mM) Ethanol 25 mg/mL (52.56 mM) Water Insoluble

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M2400 MSDS PDF

Info Sheet

M2400 Info Sheet PDF

References

Zhu B, Jin Y, Han L, et al. Proteasome inhibitor inhibits proliferation and induces apoptosis in renal interstitial fibroblasts. Pharmacol Rep. 2013;65(5):1357-65. PMID: 24399732.

Ma BM, Liu ZH, Liang ZK, et al. The proteasome inhibitor MG132 attenuates skeletal muscle atrophy in a rat model of chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2013 Jun;36(6):441-6. PMID: 24103208.

Quan R, Huang Z, Yue Z, et al. Effects of a proteasome inhibitor on the NF-κB signalling pathway in experimental osteoarthritis. Scand J Rheumatol. 2013;42(5):400-7. PMID: 23826657.

Custom Order

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