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Naphazoline is an agonist at α1-adrenergic receptors that is clinically used to treat congestion and ocular pathologies such as myasthenic blepharoptosis; it acts as a sympathomimetic and vasoconstrictor. Naphazoline inhibits erythroid differentiation and erythroleukemia cell growth through the induction of autophagy and necrotic cell death.
| Cas No. | 550-99-2 |
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| Purity | ≥97% |
| Formula | C14H14N2 • HCl |
| Formula Wt. | 246.74 |
| Chemical Name | 4,5-Dihydro-2-(1-naphthalenylmethyl)-1H-imidazole hydrochloride |
| IUPAC Name | 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride |
| Synonym | Ak-Con, Clera, Naphcon, Rhinantin, Sanorin, Strictylon |
| Melting Point | 255-260°C |
| Solubility | Freely soluble in water and alcohol. |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Fuchs R, Schraml E, Leitinger G, et al. α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism. Exp Cell Res. 2011 Oct 1;317(16):2239-51. PMID: 21781962.
Nagane Y, Utsugisawa K, Suzuki S, et al. Topical naphazoline in the treatment of myasthenic blepharoptosis. Muscle Nerve. 2011 Jul;44(1):41-4. PMID: 21491460.
Rikimaru T. Therapeutic management of endobronchial tuberculosis. Expert Opin Pharmacother. 2004 Jul;5(7):1463-70. PMID: 15212597.