• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Naringin

Naringin

Product ID N0069
Cas No. 10236-47-2
Purity ≥97%
Product Unit SizeCostQuantityStock
1 g $54.60 In stock
25 g $71.50 In stock
100 g $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Naringin is a phytoestrogen and flavanone glycoside originally found in citrus fruits that exhibits anti-angiogenic, anticancer chemotherapeutic, antioxidative, neuroprotective, cognition enhancing, nephroprotective, and anti-inflammatory activities. Naringin inhibits release of VEGF in ER+ breast cancer cells; in similar cancer models, naringin increases expression of p21 and decreases expression of survivin and β-catenin, suppressing cell and tumor growth. This compound binds estrogen receptors, acting as a selective estrogen receptor modulator (SERM) in a concentration-dependent manner. Naringin also improves colchicine-induced deficits in cognitive performance and attenuates oxidative damage by decreasing levels of malondialdehyde and nitrates and increasing activity of superoxide dismutase, catalase, and glutathione-S-transferase. Naringin also improves cognitive function and CaMKII activity in animal models of Alzheimer’s disease. Additionally, this compound inhibits gentamicin-induced increases in TNF-α, IL-6, and NF-κB and suppresses levels of Bax, caspase 3, and p53.

Product Info

Cas No.

10236-47-2

Purity

≥97%

Formula

C27H32O14

Formula Wt.

580.53

Chemical Name

7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-gluco- pyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxy- phenyl)-4H-1-benzopyran-4-one

IUPAC Name

(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

Synonym

Naringenin-7-rhamnoglucoside, Aurantiin

Melting Point

175-180°C

Solubility

Soluble in water (1 mg/ml), alcohol, acetone, and warm acetic acid

Appearance

Almost white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N0069 MSDS PDF

Info Sheet

N0069 Info Sheet PDF

Brochures

WNT Booklet

References

Sahu BD, Tatireddy S, Koneru M, et al. Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol. 2014 May 15;277(1):8-20. PMID: 24637089.

Li H, Yang B, Huang J, et al. Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. Toxicol Lett. 2013 Jul 18;220(3):219-28. PMID: 23694763.

Wang DM, Yang YJ, Zhang L, et al. Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2013 Mar 11;14(3):5576-86. PMID: 23478434.

Guo D, Wang J, Wang X, et al. Double directional adjusting estrogenic effect of naringin from Rhizoma drynariae (Gusuibu). J Ethnopharmacol. 2011 Nov 18;138(2):451-7. PMID: 21964193.

Kumar A, Dogra S, Prakash A. Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. J Med Food. 2010 Aug;13(4):976-84. PMID: 20673063.

Schindler R, Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J Nutr. 2006 Jun;136(6):1477-82. PMID: 16702307.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C086007

    CC-671

    TTK/CLK2 inhibitor.

    ≥98%
  • R1626

    Regorafenib Monohydrate

    VEGFR1/2/3, TIE2, PDGFRβ, FGFR1, c-Kit, RET, B...

    ≥99%
  • B5560

    B-type Natriuretic Peptide (1-32), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • A7203

    AS-703026

    MEK1/2 inhibitor.

    ≥98%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • B7058

    Brompheniramine Maleate

    Pheniramine derivative; histamine H1 and mAChR ...

    ≥98%
  • P6958

    Protopanaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥95%
  • F8270

    Furosemide

    Loop diuretic; NKCC symporter inhibitor, CFTR C...

    ≥97%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • L960012

    LY-3214996

    ERK1/2 inhibitor.

    ≥98%
  • D9752

    Dynasore

    Dynamin inhibitor.

    ≥98%
  • R2510

    RGD-4C

    Peptide, used to deliver conjugated drugs to ce...

    ≥95%
  • A9715

    AZD-8330

    MEK 1/2 inhibitor.

    ≥98%
  • D1792

    Dextromethorphan Hydrobromide Hydrate

    σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...

    ≥98%
  • T0008

    Tacrolimus

    Calcineurin inhibitor.

    ≥98%
  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • G7241

    GSK-461364

    PLK1 inhibitor.

    ≥99%
  • A1368

    Adrenomedullin (1-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only