LKT Labs

Biochemicals for Life Science Research

NMS-1286937

NMS-1286937

Product ID N5072
Cas No. 1034616-18-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $142.80 In stock
5 mg $228.10 In stock
10 mg $346.10 Please Inquire
Bulk Quote

Quicklinks

Description

NMS-1286937 is an inhibitor of polo-like kinase 1 (PLK1) that is currently in clinical trials as a potential treatment for various cancers; it exhibits anticancer chemotherapeutic activity. In osteosarcoma cells, NMS-1286937 induces cell cycle arrest and apoptosis and inhibits cell growth. In animal models of acute myelogenous leukemia (AML), this compound increases survival time and decreases tumor cell infiltration. Additionally, NMS-1286937 inhibits cell proliferation and induces apoptosis, cell cycle arrest, and tumor regression in cellular and animal models of colon cancer.

Product Info

Cas No.

1034616-18-6
Purity

≥98%
Formula

C24H27F3N8O3
Formula Wt.

532.52
IUPAC Name

1-(2-Hydroxyethyl)-8-{[5-(4-methyl-1-piperazinyl)-2-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Synonym

NMS1286937, NMS-P937
Solubility

DMSO 42 mg/mL warmed (78.87 mM) Ethanol 10 mg/mL warmed (18.77 mM) Water Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N5072 MSDS PDF
Info Sheet

N5072 Info Sheet PDF

References

Sero V, Tavanti E, Vella S, et al. Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance. Invest New Drugs. 2014 Dec;32(6):1167-80. PMID: 25193492.

Casolaro A, Golay J, Albanese C, et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424. PMID: 23520509.

Valsasina B, Beria I, Alli C, et al. NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16. PMID: 22319201.

Beria I, Bossi RT, Brasca MG, et al. NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74. PMID: 21470862.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4657

    Clotrimazole

    Imidazole; 14-α demethylase, H+/K+ ATPase, Na+...

    ≥97%
  • M1708

    Mecamylamine Hydrochloride

    Monoterpene; nAChR antagonist.

    ≥98%
  • A0817

    D,L-1’-Acetoxychavicol acetate

    TRPA1 agonist, xanthine oxidase inhibitor.

    ≥98%
  • S3313

    Sildenafil Citrate

    PDE5/6 inhibitor.

    ≥99%
  • P3576

    Pitavastatin Calcium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • A528251

    Angiotensin I/II (1-7)(DP-7)

    Peptide fragment

    ≥95%
  • C1876

    Cetirizine Dihydrochloride

    Histamine H1 antagonist.

    ≥99%
  • A7868

    Atropine

    Tropane alkaloid found in plants in the Solanac...

    ≥98%
  • P8118

    Puerarin

    Isoflavone daidzein derivative found in Puerari...

    ≥96%
  • L1817

    Leflunomide

    AhR agonist, dihydroorotate dehydrogenase inhib...

    ≥98%
  • P6004

    PP-242

    Dual mTORC1/mTORC2 inhibitor.

    ≥98%
  • P004080

    PAC-1

    Zinc chelator

    ≥98%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.

    ≥98%
  • P7103

    Praziquantel

    Alters membrane permeability and Ca2+ signaling...

    ≥98%
  • P0013

    P7C3

    Aminopropyl carbazole, neuroprotective.

    ≥98%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • N859610

    NVP-HDM201

    HDM2 inhibitor

    ≥99%
  • W5726

    Wogonin

    Flavonoid found in Scutellaria; CDK9 inhibitor....

    ≥98%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • M1649

    Melanoma-associated Antigen Peptide 1 (27-35), human

    Melanoma-associated antigen.

    ≥95%