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Norethindrone is a progestogen steroid hormone that is clinically used in oral contraceptives. Norethindrone decreases levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Norethindrone also decreases HDL and increases lipid peroxidation due to its high lipophilicity.
| Cas No. | 68-22-4 |
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| Purity | ≥98% |
| Formula | C20H26O2 |
| Formula Wt. | 298.42 |
| Chemical Name | 17α-17-Hydroxy-19-norpregnen-4-20-yn-3-one |
| IUPAC Name | (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10, 11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one |
| Synonym | Menzol, Micronovum, Norlutin, Utovaln |
| Melting Point | 203-204°C |
| Solubility | Insoluble in water. Soluble in acetone, ethanol, chloroform and dioxane. |
| Appearance | Off-White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shoupe D. HRT dosing regimens: continuous versus cyclic-pros and cons. Int J Fertil Womens Med. 2001 Jan-Feb;46(1):7-15. PMID: 11294619.
Saha A, Roy K, De K, et al. Effects of oral contraceptive norethindrone on blood-lipid and lipid peroxidation parameters. Acta Pol Pharm. 2000 Nov-Dec;57(6):441-7. PMID: 11243250.
Couzinet B, Young J, Brailly S, et al. The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor. J Clin Endocrinol Metab. 1996 Dec;81(12):4218-23. PMID: 8954018.