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Ophiobolin B is a naturally occurring sesterterpenoid. The ophiobolin family is known to exhibit a broad spectrum of inhibitory activity against several cell lines. Both ophiobolins A and B have also shown antifungal activity against several fungal strains.
| Cas No. | 5601-74-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H38O4 |
| Formula Wt. | 402.58 |
| Chemical Name | Ophiobolin B |
| IUPAC Name | (1~{R},3~{S},4~{R},7~{S},8~{E},11~{R},12~{S})-4,12-dihydroxy-1,4-dimethyl-12-[(2~{S})-6-methylhept-5-en-2-yl]-6-oxotricyclo[9.3.0.0^{3,7}]tetradec-8-ene-8-carbaldehyde |
| Synonym | Cochliobolin B; 3,14-Dihydroxy-5-oxoophiobola-7,19-dien-25-al; CHEMBL478388; Ophiobola-7,19-dien-25-al, 3,14-dihydroxy-5-oxo- |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Bladt TT, Durr C, Knudsen PB, et al. Bio-activity and dereplicaiton-based discovery of ophioblins and other fungal secondary metabolites targeting leukemia cells. Molecules. 2013 Nov 26;18(12):14629-14650. PMID: 24287995.
Krizsan K, Bencsik O, Nyilasi I, et al. Effect of the sesteterpene-type metabolites, ophiobolins A and B, on zygomycetes fungi. FEMS Microbiol Lett. 2010 Dec;313(2):135-140. PMID: 21054501.
Li E, Clark AM, Rotella DP, et al. Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins. J Nat Prod. 1995 Jan;58(1):74-81. PMID: 7760080.
Gianani L, Cocucci S, Pardi D, et al. Effects of ophiobolin B on cell enlargement and H(+)/K(+) exchange in maize coleoptile tissues. Planta. 1979 Jan;146(3):271-274. PMID: 24318178.