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Oxybutynin is an anti-cholinergic compound that inhibits muscarinic acetylcholine receptor (mAChR) signaling. Oxybutynin is used clinically to treat overactive bladder; alteration of mAChR signaling decreases afferent activity of C-fibers and Aδ fibers. Oxybutynin also downregulates stretch-induced c-Jun signaling and growth of bladder smooth muscle cells.
| Cas No. | 1508-65-2 |
|---|---|
| Purity | ≥98% |
| Formula | C22H31NO3 • HCl |
| Formula Wt. | 393.95 |
| Chemical Name | 4-diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate |
| IUPAC Name | 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate;hydrochloride |
| Melting Point | 129-130°C |
| Solubility | Soluble in water (50 mg/mL). Slightly soluble in chloroform, methanol. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
De Laet K, De Wachter S, Wyndaele JJ. Systemic oxybutynin decreases afferent activity of the pelvic nerve of the rat: new insights into the working mechanism of antimuscarinics. Neurourol Urodyn. 2006;25(2):156-61. PMID: 16372316.
Park JM, Bauer SB, Freeman MR, et al. Oxybutynin chloride inhibits proliferation and suppresses gene expression in bladder smooth muscle cells. J Urol. 1999 Sep;162(3 Pt 2):1110-4. PMID: 10458442.