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P55-TNFR is a peptide fragment of the P55 tumor necrosis factor (TNF) receptor. This receptor is involved in insulin sensitivity, cell death signaling, and the development of atherosclerosis. P55-TNFR also mediates inflammatory signaling and T cell proliferation.
| Purity | ≥95% |
|---|---|
| Formula | C57H95N15O22 |
| Formula Wt. | 1342.48 |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Xanthoulea S, Thelen M, Pöttgens C, et al. Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice. PLoS One. 2009 Jul 7;4(7):e6113. PMID: 19582157.
Pandey M, Tuncman G, Hotamisligil GS, et al. Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1. Am J Pathol. 2003 Mar;162(3):933-41. PMID: 12598326.
Hill GR, Teshima T, Rebel VI, et al. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol. 2000 Jan 15;164(2):656-63. PMID: 10623807
Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Endocrinology. 1998 Dec;139(12):4832-8. PMID: 9832419.
Shen Y, Li R, Shiosaki K. Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human neuronal cell line. J Biol Chem. 1997 Feb 7;272(6):3550-3. PMID: 9013604.