Description
Pantoprazole is an H+/K+ ATPase inhibitor that exhibits antacid, anti-parasitic, and anticancer chemotherapeutic activities. Pantoprazole is clinically used to treat gastroesophageal reflux disease (GERD), although its inhibition of ROCK-2 causes a decrease in gastroesophageal sphincter muscle tone. In Trichomonas, pantoprazole inhibits uridine nucleoside ribohydrolase activity. Additionally, pantoprazole increases tumor-associated macrophage recruitment in the tumor microenvironment, inhibiting tumor growth in vivo.