• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Pentoxifylline

Pentoxifylline

Product ID P1755
Cas No. 6493-05-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $71.50 In stock
50 g $153.10 In stock
100 g $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pentoxifylline is a xanthine derivative that exhibits anti-inflammatory, cardioprotective, antithrombotic, analgesic, and anti-fibrotic activities. Pentoxifylline is clinically used to treat intermittent claudication, peripheral vascular disease, and neuropathies. Pentoxifylline is a non-selective inhibitor of phosphodiesterases (PDEs) that increases cAMP levels and activates PKA; it also inhibits adenosine A2 receptors. In vitro, pentoxifylline decreases phosphorylation of IκBα and suppresses activity of NFκB. This compound also inhibits inflammation-induced hyperalgesia and separately, suppresses fibrin-induced epithelial-to-mesenchymal transition (EMT) and the development of fibrosis in animal models.

Product Info

Cas No.

6493-05-6

Purity

≥98%

Formula

C13H18N4O3

Formula Wt.

278.31

Chemical Name

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine- 2,6-dione

IUPAC Name

3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

Synonym

Azupentat, Durapental, Oxpentifylline, Rentylin, Torental, Trental, Vazofirin

Melting Point

105°C

Solubility

Soluble in water and benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P1755 MSDS PDF

Info Sheet

P1755 Info Sheet PDF

References

Fang CC, Huang JW, Shyu RS, et al. Fibrin-Induced epithelial-to-mesenchymal transition of peritoneal mesothelial cells as a mechanism of peritoneal fibrosis: effects of pentoxifylline. PLoS One. 2012;7(9):e44765. PMID: 23028611

Nowak Ł, Zurowski D, Dobrogowski J, et al. Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models. Folia Med Cracov. 2012;52(1-2):83-95. PMID: 23697217

Deree J, Martins JO, Melbostad H, et al. Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo). 2008 Jun;63(3):321-8. PMID: 18568240.

Marques LJ, Zheng L, Poulakis N, et al. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med. 1999 Feb;159(2):508-11. PMID: 9927365.

Ward A, Clissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987 Jul;34(1):50-97. PMID: 3308412.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V1745

    Veliparib

    PARP inhibitor.

    ≥99%
  • T0117

    Benzyl Analog of Taxol

    Benzyl taxol analog; potential microtubule depo...

    ≥95%
  • P2516

    S-(N-Phenylbutylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

  • C4510

    Climbazole

    14-α demethylase inhibitor.

    ≥99%
  • V024761

    Vatalanib

    Inhibitor of VEGFR1/2/3.

    ≥98%
  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • F334453

    Filipin III

    Antifungal antibiotic

    ≥95%
  • D5662

    Dopamine Hydrochloride

    Endogenous hormone neurotransmitter, involved i...

    ≥99%
  • C5864

    Coptisine Chloride, synthetic

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • R0351

    Ramoplanin

    Peptide; peptidoglycan inhibitor.

    ≥90%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • A0933

    Acitretin

    Retinoid; RARα/β/γ agonist.

    ≥98%, multiple isomers
  • R0248

    Ramatroban

    CRTH2 inhibitor, TxA2 antagonist.

    ≥98%
  • N0163

    2-(1,8-Naphthyridin-2-yl)phenol

    Naphthalene; indirect STAT1 agonist.

    ≥98%
  • O4531

    Oligomycin A

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • I7559

    Isoliquiritigenin, natural

    Chalcone; SIRT activator, GABA-A positive modul...

    ≥99%
  • M2077

    1-Methoxy-5-methylphenazinium Methyl Sulfate

    Electron carrier used to study dehydrogenase el...

    ≥98%
  • C0251

    Calcitonin Gene Related Peptide II, rat

    Calcitonin-family peptide, involved in vasodila...

    ≥95%
  • S0072

    5S rRNA modificator

    Electrophile used in 2’-hydroxyl acylation of...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only