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Pentoxifylline

Pentoxifylline

Product ID P1755
Cas No. 6493-05-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $71.50 In stock
50 g $153.10 In stock
100 g $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pentoxifylline is a xanthine derivative that exhibits anti-inflammatory, cardioprotective, antithrombotic, analgesic, and anti-fibrotic activities. Pentoxifylline is clinically used to treat intermittent claudication, peripheral vascular disease, and neuropathies. Pentoxifylline is a non-selective inhibitor of phosphodiesterases (PDEs) that increases cAMP levels and activates PKA; it also inhibits adenosine A2 receptors. In vitro, pentoxifylline decreases phosphorylation of IκBα and suppresses activity of NFκB. This compound also inhibits inflammation-induced hyperalgesia and separately, suppresses fibrin-induced epithelial-to-mesenchymal transition (EMT) and the development of fibrosis in animal models.

Product Info

Cas No.

6493-05-6

Purity

≥98%

Formula

C13H18N4O3

Formula Wt.

278.31

Chemical Name

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine- 2,6-dione

IUPAC Name

3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

Synonym

Azupentat, Durapental, Oxpentifylline, Rentylin, Torental, Trental, Vazofirin

Melting Point

105°C

Solubility

Soluble in water and benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P1755 MSDS PDF

Info Sheet

P1755 Info Sheet PDF

References

Fang CC, Huang JW, Shyu RS, et al. Fibrin-Induced epithelial-to-mesenchymal transition of peritoneal mesothelial cells as a mechanism of peritoneal fibrosis: effects of pentoxifylline. PLoS One. 2012;7(9):e44765. PMID: 23028611

Nowak Ł, Zurowski D, Dobrogowski J, et al. Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models. Folia Med Cracov. 2012;52(1-2):83-95. PMID: 23697217

Deree J, Martins JO, Melbostad H, et al. Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo). 2008 Jun;63(3):321-8. PMID: 18568240.

Marques LJ, Zheng L, Poulakis N, et al. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med. 1999 Feb;159(2):508-11. PMID: 9927365.

Ward A, Clissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987 Jul;34(1):50-97. PMID: 3308412.

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