LKT Labs

Biochemicals for Life Science Research

PF-03758309 Dihydrochloride

PF-03758309 Dihydrochloride

Product ID P2000
Cas No. 1279034-84-2
Purity ≥99%, ≥99%ee
Product Unit SizeCostQuantityStock
1 mg $105.00 In stock
5 mg $180.00 In stock
25 mg $481.00 In stock
Bulk Quote

Quicklinks

Description

PF-03758309 is an ATP-competitive inhibitor of p21-activated kinase 4 (PAK4), a kinase typically upregulated in many cancers. This compound exhibits anticancer chemotherapeutic and anti-metastatic activities. Inhibition of PAK4 inhibits cell motility, proliferation, and survival in cellular models of cancer and suppresses tumor growth in animal models of cancer. PF-03758309 also inhibits fusion and migration of preosteoclasts, osteoclast differentiation, and podosome formation in cellular models of osteoclast-related disorders.

Product Info

Cas No.

1279034-84-2
Purity

≥99%, ≥99%ee
Formula

C25H30N8OS • 2HCl
Formula Wt.

563.55
IUPAC Name

N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide;hydrochloride
Synonym

PF-3758309 .2HCl
Solubility

Soluble in DMSO, water and alcohols.
Appearance

Off white to pale yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P2000 MSDS PDF
Info Sheet

P2000 Info Sheet PDF

References

Choi SW, Yeon JT, Ryu BJ, et al. Repositioning Potential of PAK4 to Osteoclastic Bone Resorption. J Bone Miner Res. 2015 Jan 31. [Epub ahead of print]. PMID: 25640698.

Ryu BJ, Lee H, Kim SH, et al. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings Mol Cell Biochem. 2014 Apr;389(1-2):69-77. PMID: 24366569.

Murray BW, Guo C, Piraino J, et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. PMID: 20439741.

www.clinicaltrials.gov/show/NCT00932126

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F4481

    Flurbiprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • P1635

    Peiminine

    Steroidal alkaloid found in Fritillaria; M2 mAC...

    ≥98%
  • B8676

    BVT-2733

    11β-HSD1 inhibitor.

    ≥98%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • H9802

    Hyaluronic Acid Sodium (7-10 kDA)

    Glycosaminoglycan
  • A5061

    Ampalex

    Benzylpiperidine; AMPA potentiator.

    ≥98%
  • M5776

    Motilin, porcine

    Endogenous peptide hormone, involved in enteric...

    ≥98%
  • D5649

    Domperidone

    D2/3 antagonist, hERG K+ channel blocker.

    ≥98%
  • Z8401

    Z-VAD-FMK

    Non-specific caspase inhibitor used to prevent ...

    ≥95%
  • B5874

    Bosutinib

    Src and Abl inhibitor.

    ≥98%
  • A5287

    Angiotensinogen (1-14), human

    Peptide fragment, renin substrate, precursor to...

    ≥95%
  • A0401

    Abacavir

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%
  • C7097

    Cryptotanshinone

    Quinoid diterpene found in species of Salvia; S...

    ≥90%
  • I058584

    Ibotenic Acid

    Analog of glutamate

    ≥98%
  • O9257

    16-Oxokahweol

    Synthetic kahweol derivative.

    ≥95%
  • I7074

    Irsogladine Maleate

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • I1418

    Idebenone

    Synthetic quinone CoQ analog, promotes mitochon...

    ≥98%
  • S3033

    Shikimic Acid

    Cyclohexanecarboxylic acid found in various pla...

    ≥98%
  • I5208

    INCB-28060

    c-MET inhibitor.

    ≥98%