PF-03758309 Dihydrochloride

Name: PF-03758309 Dihydrochloride
SKU: P2000
Availability: InStock

Product ID P2000

Cas No. 1279034-84-2

Purity ≥99%, ≥99%ee

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

PF-03758309 is an ATP-competitive inhibitor of p21-activated kinase 4 (PAK4), a kinase typically upregulated in many cancers. This compound exhibits anticancer chemotherapeutic and anti-metastatic activities. Inhibition of PAK4 inhibits cell motility, proliferation, and survival in cellular models of cancer and suppresses tumor growth in animal models of cancer. PF-03758309 also inhibits fusion and migration of preosteoclasts, osteoclast differentiation, and podosome formation in cellular models of osteoclast-related disorders.

Product Info

Cas No.	1279034-84-2
Purity	≥99%, ≥99%ee
Formula	C₂₅H₃₀N₈OS • 2HCl
Formula Wt.	563.55
IUPAC Name	N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide;hydrochloride
Synonym	PF-3758309 .2HCl
Solubility	Soluble in DMSO, water and alcohols.
Appearance	Off white to pale yellow powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	P2000 MSDS PDF
Info Sheet	P2000 Info Sheet PDF

References

Choi SW, Yeon JT, Ryu BJ, et al. Repositioning Potential of PAK4 to Osteoclastic Bone Resorption. J Bone Miner Res. 2015 Jan 31. [Epub ahead of print]. PMID: 25640698.

Ryu BJ, Lee H, Kim SH, et al. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings Mol Cell Biochem. 2014 Apr;389(1-2):69-77. PMID: 24366569.

Murray BW, Guo C, Piraino J, et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. PMID: 20439741.

www.clinicaltrials.gov/show/NCT00932126

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

PF-03758309 Dihydrochloride

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Terbinafine Hydrochloride

Protocatechuic Acid Ethyl Ester

Mevastatin

7-Hydroxyaristolochic Acid A

Fumonisin B3

Disodium Cycloheptylaminomethylene Diphosphate

Tofacitinib Citrate

Yangonin

Emtricitabine

β-Zearalanol

Pazopanib

Theaflavin-3,3’-digallate

Asparaginase

Dihydrotanshinone

Exendin-4

Small Cardioactive Peptide B

Alamethicin

Raltegravir

LX-2343

Flufenamic Acid

Footer