• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Phenethyl Isothiocyanate

Phenethyl Isothiocyanate

Product ID P2508
Cas No. 2257-09-2
Purity ≥99%
Product Unit SizeCostQuantityStock
5 g $102.00 In stock
10 g $193.90 In stock
50 g $816.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Phenethyl isothiocyanate (PEITC) is found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, PEITC increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in Jurkat T cells and other cellular models. PEITC increases activation of JNK1, one potential mechanism behind its regulation of phase II detoxifying enzyme gene expression. Additionally, PEITC decreases levels of Bcl-xl and increases levels of Bax, also decreasing the mitochondrial membrane potential and inducing intracellular influx of free Ca2+, resulting in cell death. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. In glioma cells, PEITC alters PI3K/MAPK signaling to inhibit accumulation of HIF-1α and secretion of VEGF during hypoxia.

Refractive index:n20/D 1.5888(lit.)

Product Info

Cas No.

2257-09-2

Purity

≥99%

Formula

C9H9NS

Formula Wt.

163.24

Chemical Name

2-Isothiocyanatoethylbenzene

IUPAC Name

2-isothiocyanatoethylbenzene

Synonym

Phenylethyl mustard oil

Solubility

Insoluble in water. Soluble in ethanol, DMSO. Density: 1.094g/ml

Appearance

Clear Pale Yellow Liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2508 MSDS PDF

Info Sheet

P2508 Info Sheet PDF

References

Tusskorn O, Senggunprai L, Prawan A, et al Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells. BMC Cancer. 2013 Dec 5;13(1):571. PMID: 24304591.

Stan SD, Singh SV, Whitcomb DC, et al. Phenethyl Isothiocyanate Inhibits Proliferation and Induces Apoptosis in Pancreatic Cancer Cells In Vitro and in a MIAPaca2 Xenograft Animal Model. Nutr Cancer. 2013 Nov 6. [Epub ahead of print]. PMID: 24195616.

Gupta B, Chiang L, Chae K, et al. Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1α and VEGF expression in human glioma cells. Food Chem. 2013 Dec 1;141(3):1841-6. PMID: 23870899.

Thomson SJ, Brown KK, Pullar JM, et al. Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Cancer Res. 2006 Jul 1;66(13):6772-7. PMID: 16818653.

Yu R, Mandlekar S, Harvey KJ, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998 Feb 1;58(3):402-8. PMID: 9458080.

Yu R, Jiao JJ, Duh JL, et al. Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1. Cancer Res. 1996 Jul 1;56(13):2954-9. PMID: 8674048.

Guo Z, Smith TJ, Wang E, et al. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993 Jun;14(6):1167-73. PMID: 8508504.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R3347

    Riluzole

    Benzothiazole; TRPC5 agonist, PTR1 inhibitor, v...

    ≥98%
  • D5792

    Doxofylline

    Xanthine derivative; PDE inhibitor.

    ≥98%
  • C0264

    L-Carnitine Tartrate

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • G0246

    Galantamine Hydrobromide

    Alkaloid found in Galanthus, Narcissus, Leucoju...

    ≥98%
  • B8070

    2-tert-Butyl-4-Hydroxyanisole

    BHA derivative, antioxidative food and cosmetic...

    ≥99% single isomer
  • G3552

    20S-Ginsenoside Rg3

    Triterpene saponin found in Panax; Kv7.1 K+ cha...

    ≥98%
  • R0110

    Ractopamine Hydrochloride

    β1/2-adrenergic agonist.

    ≥97%
  • C2900

    CH5424802

    ALK inhibitor.

    ≥99%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • E4418

    β-Elemene

    Sesquiterpene found in various plant sources. <...

    ≥98%
  • B3272

    Bis(3,5-dibromosalicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥91%
  • I4800

    Imatinib free base

    Inhibitor of Abl, c-Kit, and PDGFR.

    ≥99%
  • A5033

    4-Aminosalicylic Acid

    Dihydrofolate reductase inhibitor.

    ≥98%
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • S9753

    Synephrine

    Endogenous alkaloid also found in citrus fruits...

    ≥98%
  • G7344

    GSK-2334470

    PI3K and PDK1 inhibitor.

    ≥99%, ≥99%ee
  • C211324

    CFI-400945

    PLK4 inhibitor.

    ≥98%
  • S8248

    Sulfamethoxazole

    Sulfonamide; PABA inhibitor.

    ≥98%
  • K0034

    Kahweol Eicosanate

    Diterpene found in coffee beans.

    ≥98%
  • R0249

    Ramipril

    ACE inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only