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Phentolamine Methanesulfonate

Phentolamine Methanesulfonate

Product ID P2818
Cas No. 65-28-1
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $61.10 In stock
100 mg $102.00 In stock
500 mg $306.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Phentolamine is a nonselective α-adrenergic receptor antagonist that exhibits vasodilatory and antihypertensive activities. Phentolamine is occasionally used to treat erectile dysfunction. In vivo, phentolamine inhibits fructose-induced increases in blood pressure and activates ATP-sensitive K+ channels, altering Ca2+ signaling.

Product Info

Cas No.

65-28-1

Purity

≥98%

Formula

C17H19N3O • CH3SO3H

Formula Wt.

377.46

Chemical Name

3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methyl- phenyl)amino]phenol methanesulfonate

IUPAC Name

3-[N-(4, 5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid

Synonym

Phentolamine mesylate, Regitine, Rogitine

Melting Point

177-181°C

Solubility

Soluble in water, alcohol and chloroform.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P2818 MSDS PDF

Info Sheet

P2818 Info Sheet PDF

References

Zhou K, Kumar U, Yuen VG, et al. The effects of phentolamine on fructose-fed rats. Can J Physiol Pharmacol. 2012 Aug;90(8):1075-85. PMID: 22783820.

Ahn SW, Kim SH, Kim JH, et al. Phentolamine inhibits the pacemaker activity of mouse interstitial cells of Cajal by activating ATP-sensitive K+ channels. Arch Pharm Res. 2010 Mar;33(3):479-89. PMID: 20361315.

Dinsmore WW, Wyllie MG. Vasoactive intestinal polypeptide/phentolamine for intracavernosal injection in erectile dysfunction. BJU Int. 2008 Sep;102(8):933-7. PMID: 18485029.

Custom Order

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