Description
Psoralen is a furanocoumarin compound originally found in Psoralea coryfolia that exhibits anti-angiogenic activity. Psoralen is currently used to treat psoriasis with the additional of UVA light. Psoralen inhibits angiogenesis and induces G0/G1 phase cell cycle arrest and apoptosis in endothelial cells. This compound also inhibits topoisomerase I and induces DNA interstrand crosslinks and monoadducts, displaying carcinogenic potential as well.