Description
Raltegravir is an antiviral compound that inhibits HIV integrase; it is clinically used to treat HIV infection. In pre-clinical models, raltegravir decreases infection rates by preventing insertion of HIV-1 DNA into the host genome.
Product Unit Size | Cost | Quantity | Stock |
---|
Raltegravir is an antiviral compound that inhibits HIV integrase; it is clinically used to treat HIV infection. In pre-clinical models, raltegravir decreases infection rates by preventing insertion of HIV-1 DNA into the host genome.
Cas No. | 518048-05-0 |
---|---|
Purity | ≥99% |
Formula | C20H21FN6O5 |
Formula Wt. | 444.42 |
IUPAC Name | N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}-2-propanyl)-6-oxo-1,6-dihydro-4-pyrimidinecarboxamide |
Synonym | MK-0518 |
Solubility | soluble in water, slightly soluble in methanol, very slightly soluble in ethanol and acetonitrile and insoluble in isopropanol. The solubility of raltegravir increases with increasing pH such that its solubility in water is approx. 71 mg/mL. Its pKa is 6.3 |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Taramasso L, Madeddu G, Ricci E, et al. Raltegravir-based therapy in a cohort of HIV/HCV co-infected individuals. Biomed Pharmacother. 2015 Feb;69:233-6. PMID: 25661363.
Mouscadet JF, Tchertanov L. Raltegravir: molecular basis of its mechanism of action. Eur J Med Res. 2009 Nov 24;14 Suppl 3:5-16. PMID: 19959411.
Hicks C, Gulick RM. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9. PMID: 19231980.
FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...
Induces DNA strand breakage.
Folate source co-administered with methotrexate...
Nitroimidazole, binds DNA; nucleic acid synthes...
Triterpene sapogenin found in species of Panax;...
Alcoholic β-glucoside found in willow bark, sa...
Synthetic nitrile compound
Casein kinase 1 inhibitor.
ERK1/2 inhibitor.
Wortmannin analog; PI3K inhibitor.
Thiazolidinedione; PPARα/γ agonist, mitoNEET ...
Thiamine, coccidiostat; thiamine transporter in...
Peptide hormone found in Solanaceae family plan...
ACE inhibitor.
Triterpene saponin found in Panax; Kv7.1 K+ cha...
AKT inhibitor, potential ROCK, p70S6K, PKA, MKK...
May be useful against COVID-19
Indoleamine-2,3-dioxygenase inhibitor.
NSAID; TREK1 K+ potentiator, voltage-gated Na+ ...
Polyether Ca2+ ionophore.