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Risperidone

Risperidone

Product ID R3475
Cas No. 106266-06-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $141.00 In stock
250 mg $267.50 In stock
1 g $788.90 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • References
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Description

Risperidone is a benzisoxazole atypical antipsychotic that also exhibits antidepressant, anti-inflammatory, and neuroprotective activities. Risperidone acts as an antagonist at D2 receptors and 5-HT2A receptors and as an agonist at 5-HT7 receptors. In vivo, risperidone increases release of DA, 5-HT, and NE in the frontal cortex. Risperidone is also a partial uncompetitive inhibitor of D-amino acid oxidase, which inhibits oxidation of D-serine, an NMDA receptor agonist associated with the onset of schizophrenia; risperidone also inhibits D-amino acid-induced cell death in vitro. In animal models of neuroinflammation or encephalitis, risperidone increases expression of PPARγ and decreases LPS-induced expression of TNF-α, IL-1β, COX, p38 MAPK, and NF-κB.

Product Info

Cas No.

106266-06-2

Purity

≥98%

Formula

C23H27FN4O2

Formula Wt.

410.49

Chemical Name

3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[2,1-b]pyrimidin-4-one

IUPAC Name

3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6, 7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

Melting Point

170C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3475 MSDS PDF

Info Sheet

R3475 Info Sheet PDF

References

Kamińska K, Gołembiowska K, Rogóż Z. Effect of risperidone on the fluoxetine-induced changes in extracellular dopamine, serotonin and noradrenaline in the rat frontal cortex. Pharmacol Rep. 2013;65(5):1144-51. PMID: 24399710.

MacDowell KS, García-Bueno B, Madrigal JL, et al. Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation. Int J Neuropsychopharmacol. 2013 Feb;16(1):121-35. PMID: 22176740.

Kozielska M, Johnson M, Pilla Reddy V, et al. Pharmacokinetic-pharmacodynamic modeling of the D2 and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res. 2012 Jul;29(7):1932-48. PMID: 22437487.

Abou El-Magd RM, Park HK, Kawazoe T, et al. The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia. J Psychopharmacol. 2010 Jul;24(7):1055-67. PMID: 19329549.

Toohey N, Klein MT, Knight J, et al. Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists". Mol Pharmacol. 2009 Sep;76(3):552-9. PMID: 19509219.

Potkin SG, Saha AR, Kujawa MJ, et al. Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder. Arch Gen Psychiatry. 2003 Jul;60(7):681-90. PMID: 12860772.

Farde L, Nyberg S, Oxenstierna G, et al. Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients. J Clin Psychopharmacol. 1995 Feb;15(1 Suppl 1):19S-23S. PMID: 7537284.

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