RITA

Name: RITA
SKU: R3476
Availability: InStock

Product ID R3476

Cas No. 213261-59-7

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Reactivation of p53 and induction of tumor cell apoptosis (RITA) is an activator of p53 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In vivo, RITA downregulates expression of VEGF, HIF-1α, p21, and HDM2. In cellular and animal models of neuroblastoma, RITA inhibits expression of N-Myc, AurK, Mcl-1, Bcl-2, MDM2, and MDMX, inducing apoptosis and inhibiting growth. Similar effects are observed in models of gastrointestinal stromal tumors and cervical carcinoma.

Product Info

Cas No.	213261-59-7
Purity	≥98%
Formula	C₁₄H₁₂O₃S₂
Formula Wt.	292.37
Chemical Name	[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
IUPAC Name	[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
Synonym	NSC 652287; RITA (NSC 652287); p53 Activator III, RITAReactivation of p53 and induction of tumor cell apoptosis
Solubility	Soluble in DMSO (58 mg/ml at 25° C), ethanol (8 mg/ml at 25° C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25° C).

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	R3476 MSDS PDF
Info Sheet	R3476 Info Sheet PDF

References

Burmakin M, Shi Y, Hedström E, et al. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clin Cancer Res. 2013 Sep 15;19(18):5092-103. PMID: 23864164.

Henze J, Mühlenberg T, Simon S, et al. p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PLoS One. 2012;7(5):e37776. PMID: 22662219.

Zhao CY, Szekely L, Bao W, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70(8):3372-81. PMID: 20395210.

Yang J, Ahmed A, Poon E, et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol. 2009 Apr;29(8):2243-53. PMID: 19223463.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

RITA

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

2′,3′-Dideoxyinosine

Artesunate

Buflomedil Hydrochloride

C59

L-Carnitine

Mastoparan 7

Olanzapine

Kendomycin

Idebenone

Proxymetacaine Hydrochloride

Valiltramiprosate

Dacomitinib Anhydrous

Calcimycin

Naltriben

Dimebon Dihydrochloride

D-Luciferin, firefly, Free Acid

SN-011

Terazosin Hydrochloride Dihydrate

Baricitinib

Angiotensin II, human

Footer