LKT Labs

Biochemicals for Life Science Research

RITA

RITA

Product ID R3476
Cas No. 213261-59-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $180.30 In stock
10 mg $315.40 In stock
25 mg $601.00 In stock
Bulk Quote

Quicklinks

Description

Reactivation of p53 and induction of tumor cell apoptosis (RITA) is an activator of p53 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In vivo, RITA downregulates expression of VEGF, HIF-1α, p21, and HDM2. In cellular and animal models of neuroblastoma, RITA inhibits expression of N-Myc, AurK, Mcl-1, Bcl-2, MDM2, and MDMX, inducing apoptosis and inhibiting growth. Similar effects are observed in models of gastrointestinal stromal tumors and cervical carcinoma.

Product Info

Cas No.

213261-59-7
Purity

≥98%
Formula

C14H12O3S2
Formula Wt.

292.37
Chemical Name

[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
IUPAC Name

[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
Synonym

NSC 652287; RITA (NSC 652287); p53 Activator III, RITAReactivation of p53 and induction of tumor cell apoptosis
Solubility

Soluble in DMSO (58 mg/ml at 25° C), ethanol (8 mg/ml at 25° C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25° C).

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

R3476 MSDS PDF
Info Sheet

R3476 Info Sheet PDF

References

Burmakin M, Shi Y, Hedström E, et al. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clin Cancer Res. 2013 Sep 15;19(18):5092-103. PMID: 23864164.

Henze J, Mühlenberg T, Simon S, et al. p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PLoS One. 2012;7(5):e37776. PMID: 22662219.

Zhao CY, Szekely L, Bao W, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70(8):3372-81. PMID: 20395210.

Yang J, Ahmed A, Poon E, et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol. 2009 Apr;29(8):2243-53. PMID: 19223463.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P698583

    Prostaglandin E2

    principal metabolic product of COX-2

    ≥98%
  • P7034

    Prion Peptide (106-126), human

    Synthetic peptide fragment, prion protein analo...

    ≥95%
  • A4438

    Allatostatin I

    Neuropeptide found in insects; juvenile hormone...

    ≥95%
  • B5648

    Bombesin

    GRP analog, found in Bombina; bombesin and GRP ...

    ≥95%
  • R6052

    Recombinant Mycoplasma Pneumonia Antigen

    Pneumonia antigen
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • O7992

    OTX-015

    BRD2/3/4 inhibitor.

    ≥98%
  • G8850

    GW-5074

    c-Raf inhibitor.

    ≥98%
  • R8178

    Rutaecarpine

    Indoloquinazoline alkaloid found in Evodia; COX...

    ≥98%
  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • L1735

    Levitide

    Antimicrobial peptide found in amphibians.

    ≥95%
  • C0048

    Cambinol

    SIRT inhibitor.

    ≥98%
  • G124088

    GDC-1971

    SHP2 inhibitor

    ≥99%
  • M5675

    Motilin, canine

    Endogenous peptide hormone; motilin agonist.

    ≥95%
  • D0244

    Dalcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • K0144

    Kallikrein Inhibitor

    Peptide; serine protease inhibitor.

    ≥95%
  • P8168

    Puromycin Dihydrochloride

    Protein synthesis inhibitor, DPP2 and metallope...

    ≥98%
  • D3210

    Diclofenac free acid

    Somewhat selective in inhibiting COX-2 over COX...

    ≥99%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%
  • C9779

    Cytisine

    Alkaloid found in Fabaceae family plants; α3β...

    ≥98%