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S-(N-Phenylbutylthiocarbamoyl)-glutathione

S-(N-Phenylbutylthiocarbamoyl)-glutathione

Product ID P2514
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $452.90 Please Inquire
10 mg $804.80 Please Inquire
25 mg $1,635.20 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

S-(N-Phenylbutylthiocarbamoyl)-glutathione (PBITC) is a conjugate of phenylbutylisothiocyanate and glutathione. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, PBITC increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione-S-transferase in vitro and in vivo.

Product Info

Purity

≥98%

Formula

C21H30N4O6S2

Formula Wt.

498.62

Chemical Name

S-(N-Phenylbutylthiocarbamoyl)-glutathione

Synonym

Phenylbutylisothiocyanate-glutathione

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2514 MSDS PDF

Info Sheet

P2514 Info Sheet PDF

References

Son HY, Nishikawa A, Furukawa F, et al. Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters. Cancer Lett. 2000 Nov 28;160(2):141-7. PMID: 11053643.

Yu R, Mandlekar S, Harvey KJ, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998 Feb 1;58(3):402-8. PMID: 9458080.

Guo Z, Smith TJ, Wang E, et al. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993 Jun;14(6):1167-73. PMID: 8508504.

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