• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Silybin

Silybin

Product ID S3343
Cas No. 802918-57-6
Purity ≥97%
Product Unit SizeCostQuantityStock
500 mg $41.00 In stock
1 g $50.90 In stock
5 g $153.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Silybin is a phytoestrogen and flavonoid originally found in the seeds of the milk thistle plant (Silybum). Silybin exhibits anti-diabetic, anti-inflammatory, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In cellular and animal models of hepatocellular carcinoma, silybin increases expression of TRAIL and DR-5, activates caspase signaling, and decreases tumor growth and inflammatory cytokine release. In animal models of diabetes, silybin decrease Hb1Ac levels as well as serum triglycerides, cholesterol, and glucose in pancreatic β cells. Additionally, silybin inhibits IL-1β-induced pro-inflammatory cytokine expression and suppresses translocation of NF-κB in vitro. In animal models, this compound suppresses expression of HIF-1α and VEGF, decreases microvessel density, and delays UV-induced carcinogenesis. Stimulates vascular differentiation in mouse embryonic stem cells.

Product Info

Cas No.

802918-57-6

Purity

≥97%

Formula

C25H22O10

Formula Wt.

482.44

Chemical Name

(2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3- methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin- 6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran- 4-one AND (2R,3R)-2-[(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3- methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin- 6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran- 4-one

IUPAC Name

(2R,3R)-3,5,7-trihydroxy-2-[(2R, 3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1, 4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one

Synonym

Silibinin, Silybum substance E6, Silymarin I, Silybin A + B

Melting Point

167-180°C(dec.)

Solubility

Soluble in acetone, ethyl acetate, methanol or ethanol. Practically insoluble in water.

Appearance

White to light yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S3343 MSDS PDF

Info Sheet

S3343 Info Sheet PDF

References

Sato M, Murakami K, Uno M, et al. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid-beta aggregation. Biosci Biotechnol Biochem. 2013;77(5):1100-1103. PMID: 23649236.

Bousserouel S, Bour G, Kauntz H, et al. Silibinin inhibits tumor growth in a murine orthotopic hepatocarcinoma model and activates the TRAIL apoptotic signaling pathway. Anticancer Res. 2012 Jul;32(7):2455-62. PMID: 22753701.

Wang Q, Liu M, Liu WW, et al. In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell. J Asian Nat Prod Res. 2012;14(5):413-23. PMID: 22423887.

Au AY, Hasenwinkel JM, Frondoza CG. Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures. J Vet Pharmacol Ther. 2011 Apr;34(2):120-9. PMID: 21395602.

Gu M, Singh RP, Dhanalakshmi S, et al. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res. 2007 Apr 1;67(7):3483-91. PMID: 17409458.

Lee MH, Huang Z, Kim DJ, et al. Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth. Cancer Prev Res (Phila). 2013 May;6(5):455-465. PMID: 23447564.

Ali E, Sharifpanah F, et al. Silibinin from Silybum marianum Stimulates Embryonic Stem Cell Vascular Differentiation via the STAT3/PI3-K/AKT Axis and Nitric Oxide. Planta Med. 2018 Jul;84(11):768-778. PMID: 29329462.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T2835

    6-Thioguanine

    Nucleotide (guanine) analog, prevents guanine s...

    ≥90%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • N5605

    Nobiletin

    Polymethoxylated flavone found in citrus fruits...

    ≥97%
  • T0102

    7-epi-Taxol

    Taxane found in Taxus; potential microtubule de...

    ≥95%
  • P3076

    PHT-427

    PDK1 and Akt inhibitor.

    ≥98%
  • D3215

    Didymin

    Flavonoid glycoside found in citrus fruit.

    ≥98%
  • D8276

    Dutasteride

    5-α-Reductase inhibitor.

    ≥99%
  • P1202

    PD-325901

    MEK1/2 and Raf inhibitor.

    ≥99%
  • T9969

    Tyrphostin AG490

    JAK2 inhibitor, potential EGFR inhibitor.

    ≥98%
  • A6979

    Dihydroartemisinin

    Sesquiterpene lactone derived from Artemesia; m...

    ≥96%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%
  • G1653

    Genistin

    Isoflavone found in soy; SERM.

    ≥98%
  • D1769

    Dermorphin

    Opioid peptide; μOR agonist.

    ≥96%
  • U6854

    Urocortin, human

    Endogenous peptide hormone, involved in feeding...

    ≥98%
  • E6783

    R-Equol

    Isoflavone, phytoestrogen found in soy

    ≥98%
  • S1061

    Small Cardioactive Peptide B

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • A7210

    L-(+)-Ascorbic Acid

    Form of vitamin C found in various plant and fo...

    ≥98%
  • A4935

    6-Aminocaproic Acid

    Protease inhibitor.

    ≥98%
  • M177521

    Menaquinone-7

    2-methyl-1,4-naphthoquinone derivative

    98%
  • D3300

    (Z)-1,-Bis(2-methoxy-5-(trifluoromethyl)phenyl)diazene oxide

    Azoxy compound

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only