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Simufilam

Simufilam

Product ID S336505
Cas No. 1224591-33-6
Purity
Product Unit SizeCostQuantityStock
1 mg $102.90 Please Inquire
5 mg $257.30 Please Inquire
25 mg $656.30 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Simufilam was first introduced as having the potential to reduce biomarkers of Alzheimer’s disease. The original data has since become suspect and could not be found. Fraud charges have been filed by the SEC. Simufilam may or may not have some useful bioactivities. The proper research, with proper data collection and analysis, is still to be done.

Product Info

Cas No.

1224591-33-6

Formula

C15H21N3O

Formula Wt.

259.35

Chemical Name

1-benzyl-8-methyl-1,4,8-triazaspiro(4.5)decan-2-one

IUPAC Name

4-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-3-one

Synonym

PTI-125; PTI-910; C0105; 1,4,8-Triazaspiro(4.5)decan-2-one, 8-methyl-1-(phenylmethyl)-

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

S336505 Info Sheet PDF

References

Pillar C. Research backing experimental Alzheimer’s drug was first target of suspicion. Science. 2022 Jul 22;377(6604):363. PMID: 35862516

Pillar C. Probe of Alzheimer’s studies finds ‘egregious misconduct’. Science. 2023 Oct 20;382(6668):251-252. PMID: 37856608

Dyer O. Scientist who worked on Cassava’s Alzheimer drug simufilam charged with fraud. BMJ. 2024 Jul 15: 386:q1568. PMID: 39009358

Frontiers Editorial Office. Expression of concern: simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes. Front Aging. 2024 Aug 22:5:1483030. PMID: 39239266

Pillar C. Firm misled investors on Alzheimer’s drug, SEC charges. Science. 2024 Oct 4;386(6717):15. PMID: 39361735

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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