• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Splitomicin

Splitomicin

Product ID S6247
Cas No. 5690-03-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
10 mg $126.00 In stock
25 mg $262.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Splitomicin is a cell-permeable lactone that acts as an inhibitor of sirtuins 1 and 2 (SIRT1, SIRT2); sirtuins are considered class III histone deacetylases (HDACs). Splitomicin displays anti-inflammatory, antioxidative, and antithrombotic activities. In vitro, splitomicin promotes translocation of FOXO3a, decreasing cell motility and enhancing activity of paclitaxel. In neutrophils, splitomicin decreases production of superoxide anions, suppresses activation of ERK, and increases levels of cAMP. In other cellular models, this compound inhibits thrombin-induced platelet aggregation, preventing increases in thromboxane B2 (TxB2) and release of intracellular Ca2+; this compound may also inhibit phosphodiesterases. Splitomicin also alters RNA splicing activity.

Product Info

Cas No.

5690-03-9

Purity

≥98%

Formula

C13H10O2

Formula Wt.

198.22

IUPAC Name

1,2-dihydrobenzo[f]chromen-3-one

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S6247 MSDS PDF

Info Sheet

S6247 Info Sheet PDF

References

Hori YS, Kuno A, Hosoda R, et al. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS One. 2013 Sep 11;8(9):e73875. PMID: 24040102.

Bonezzi K, Belotti D, North BJ, et al. Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. Neoplasia. 2012 Sep;14(9):846-54. PMID: 23019416.

Liu FC, Day YJ, Liou JT, et al. Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway. Eur J Pharmacol. 2012 Aug 5;688(1-3):68-75. PMID: 22634165.

Liu FC, Liao CH, Chang YW, et al. Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release. Thromb Res. 2009 Jun;124(2):199-207. PMID: 19327818.

Kuhn AN, van Santen MA, Schwienhorst A, et al. Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA. 2009 Jan;15(1):153-75. PMID: 19029308.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F3354

    Finasteride

    Steroid 5-α-reductase inhibitor.

    ≥98%
  • D3214

    2′,3′-Dideoxyinosine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • E5241

    Met-Enkephalin

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • F0275

    Fasudil Hydrochloride

    ROCK inhibitor.

    ≥98%
  • K0023

    K252c

    Staurosporine analog; PKC and PKA inhibitor.

    ≥98%
  • V3326

    Virginiamycin S1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥99%
  • P2997

    Phytic Acid, 40-50 wt% aqueous solution

    Saturated cyclic acid used to store phosphorus ...

    ≥40%
  • R0212

    Radicicol

    Benzoquinone ansamycin; topoisomerase VI-B, HSP...

    ≥96%
  • O0829

    Ochratoxin A

    Mycotoxin produced by Aspergillus and Penicillu...

    ≥98%
  • B6918

    Brevetoxin 3

    Polyether neurotoxin found in Karenia brevis; N...

    ≥95%
  • V0245

    Valdecoxib

    NSAID; CB1 agonist, COX-2 inhibitor.

    ≥98%
  • A6234

    Apigenin

    Flavonoid found in various plant sources; GABA-...

    ≥98%
  • C2942

    Mechlorethamine Hydrochloride

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • S8147

    Sulindac Sulfide

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • S1606

    Secretin, porcine

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • C9881

    Cytochalasin D

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • C0147

    Calcium Folinate Pentahydrate

    Folate source co-administered with methotrexate...

    ≥95%
  • P005095

    N-Debenzoylpaclitaxel

    Paclitaxel derivative

    ≥95%
  • G124090

    GDC-6036

    KRAS inhibitor

    ≥98%
  • T1754

    Tenatoprazole

    H+/K+ ATPase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only