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SU-5402

SU-5402

Product ID S801001
Cas No. 215543-92-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.30 In stock
25 mg $333.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

SU-5402 is an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR). In multiple myeloma, SU5402 worked with PD173074 to supress tumor growth via FGFR3 inhibition. SU5402 was used to examine the role of FGFR during neural crest differentiation, where its inhibition promoted human pluripotent stem cells to commit to a neural crest cell fate.

Product Info

Cas No.

215543-92-3

Purity

≥98%

Formula

C17H16N2O3

Formula Wt.

296.33

IUPAC Name

3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

Synonym

SU5402; 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S801001 MSDS PDF

Info Sheet

S801001 Info Sheet PDF

References

Sun L., Tran N., et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 42(25):5120-30 (1999). PMID: 10602697.

Grand E., Chase A., et al. Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia. 18(5):962-6 (2004). PMID: 15029211.

Jaroonwitchawan T., Muangchan P., et al. Inhibition of FGF signaling accelerates neural crest cell differentiation of human pluripotent stem cells. Biochem Biophys Res Commun. 481(1-2):176-181 (2016). PMID: 27816457.

Custom Order

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