Sumatriptan Succinate

Name: Sumatriptan Succinate
SKU: S8151
Availability: InStock

Product ID S8151

Cas No. 103628-48-4

Purity ≥99%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Sumatriptan is a tryptamine agonist at 5-HT1B/1D receptors that is clinically used to treat migraines. Sumatriptan exhibits vasoconstrictive and gastrointestinal motility modulating activities. The anti-migraine activity of sumatriptan is likely due to its vasoconstrictive activity and ability to decrease the release of substance P and CGRP. Sumatriptan also increases gastric relaxation and delays gastric emptying. Additionally, this compound inhibits 5-HT- and capsaicin-induced signaling of transient receptor potential vanilloid (TRPV1) channels and release of CGRP in vitro and in vivo.

Product Info

Cas No.	103628-48-4
Purity	≥99%
Formula	C₁₄H₂₁N₃O₂S • C₄H₆O₄
Formula Wt.	413.49
Chemical Name	3-[2-(Dimethyl-amin)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate; GR-43175C
IUPAC Name	butanedioic acid;1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N- methylmethanesulfonamide
Melting Point	165-166°C
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	S8151 MSDS PDF
Info Sheet	S8151 Info Sheet PDF

References

Blumenfeld A, Gennings C, Cady R. Pharmacological synergy: the next frontier on therapeutic advancement for migraine. Headache. 2012 Apr;52(4):636-47. PMID: 22221151.

Loyd DR, Weiss G, Henry MA, et al. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain. 2011 Oct;152(10):2267-76. PMID: 21737202.

Muñoz-Islas E, Lozano-Cuenca J, González-Hernández A, et al. Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Eur J Pharmacol. 2009 Aug 1;615(1-3):133-8. PMID: 19460365.

Moro E, Crema F, De Ponti F, et al. Triptans and gastric accommodation: pharmacological and therapeutic aspects. Dig Liver Dis. 2004 Jan;36(1):85-92. PMID: 14971822.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Sumatriptan Succinate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Phenethyl Glucosinolate Potassium

BVT-2733

Nefazodone Hydrochloride

Substance P (7-11)

Bifonazole

Dihydrotanshinone

Bafilomycin A1

Zerumbone

Lisinopril Dihydrate

LY-2606368

Temsirolimus

Fenbufen

10-Deacetyltaxol C

Lycopene

Recombinant HIV-1 gp-41

Darunavir

Benzydamine Hydrochloride

Kanamycin B

Norfloxacin

Reveromycin A

Footer