LKT Labs

Biochemicals for Life Science Research

Sumatriptan Succinate

Sumatriptan Succinate

Product ID S8151
Cas No. 103628-48-4
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $211.40 In stock
250 mg $408.50 In stock
1 g $1,184.80 In stock
Bulk Quote

Quicklinks

Description

Sumatriptan is a tryptamine agonist at 5-HT1B/1D receptors that is clinically used to treat migraines. Sumatriptan exhibits vasoconstrictive and gastrointestinal motility modulating activities. The anti-migraine activity of sumatriptan is likely due to its vasoconstrictive activity and ability to decrease the release of substance P and CGRP. Sumatriptan also increases gastric relaxation and delays gastric emptying. Additionally, this compound inhibits 5-HT- and capsaicin-induced signaling of transient receptor potential vanilloid (TRPV1) channels and release of CGRP in vitro and in vivo.

Product Info

Cas No.

103628-48-4
Purity

≥99%
Formula

C14H21N3O2S • C4H6O4
Formula Wt.

413.49
Chemical Name

3-[2-(Dimethyl-amin)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate; GR-43175C
IUPAC Name

butanedioic acid;1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N- methylmethanesulfonamide
Melting Point

165-166°C
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S8151 MSDS PDF
Info Sheet

S8151 Info Sheet PDF

References

Blumenfeld A, Gennings C, Cady R. Pharmacological synergy: the next frontier on therapeutic advancement for migraine. Headache. 2012 Apr;52(4):636-47. PMID: 22221151.

Loyd DR, Weiss G, Henry MA, et al. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain. 2011 Oct;152(10):2267-76. PMID: 21737202.

Muñoz-Islas E, Lozano-Cuenca J, González-Hernández A, et al. Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Eur J Pharmacol. 2009 Aug 1;615(1-3):133-8. PMID: 19460365.

Moro E, Crema F, De Ponti F, et al. Triptans and gastric accommodation: pharmacological and therapeutic aspects. Dig Liver Dis. 2004 Jan;36(1):85-92. PMID: 14971822.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F5874

    Fosfomycin Calcium

    MurA and isopentenyl mevalonate kinase inhibito...

    ≥95%
  • U6860

    Urocortin III, mouse

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • S8248

    Sulfamethoxazole

    Sulfonamide; PABA inhibitor.

    ≥98%
  • G4481

    Glucagon-like Peptide I Amide (7-36), human

    Endogenous peptide hormone, GLP-1 fragment, inv...

    ≥95%
  • P4132

    PKI-402

    p110α PI3K and mTOR inhibitor.

    ≥98%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.

    ≥99%
  • P200091

    PF-07104091

    CDK2 inhibitor

    ≥98%
  • T1025

    D-Seco Paclitaxel

    D-Seco Paclitaxel is an impurity in the product...

    ≥90%
  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • S0049

    Salmon Calcitonin Acetate

    Peptide, involved in feeding behavior and insul...

    ≥95%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity
  • H5748

    D,L-Homocysteine Thiolactone Hydrochloride

    Heterocyclic derivative of cysteine, alters pro...

    ≥99%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • M0803

    MC1568

    HDAC inhibitor. May reduce blood pressure in hy...

    ≥98%
  • P3576

    Pitavastatin Calcium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • A4678

    Alternariol-9-methyl Ether

    Mycotoxin produced by Alternaria; oxidative pho...

    ≥98%
  • H1658

    Heparin Sodium

    Endogenous glycosaminoglycan that is produced b...

    Bioassay ≥140 U/mg
  • S8344

    R,S-(±)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥98%
  • A761001

    AT-7519 free base

    ATP competitive CDK inhibitor.

    ≥98%
  • P0932

    PCI-32765

    BTK and IL-2-inducible kinase inhibitor.

    ≥99%