LKT Labs

Biochemicals for Life Science Research

Sumatriptan Succinate

Sumatriptan Succinate

Product ID S8151
Cas No. 103628-48-4
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $113.00 In stock
100 mg $211.00 In stock
250 mg $409.00 In stock
1 g $1,185.00 In stock
Bulk Quote

Quicklinks

Description

Sumatriptan is a tryptamine agonist at 5-HT1B/1D receptors that is clinically used to treat migraines. Sumatriptan exhibits vasoconstrictive and gastrointestinal motility modulating activities. The anti-migraine activity of sumatriptan is likely due to its vasoconstrictive activity and ability to decrease the release of substance P and CGRP. Sumatriptan also increases gastric relaxation and delays gastric emptying. Additionally, this compound inhibits 5-HT- and capsaicin-induced signaling of transient receptor potential vanilloid (TRPV1) channels and release of CGRP in vitro and in vivo.

Product Info

Cas No.

103628-48-4
Purity

≥99%
Formula

C14H21N3O2S • C4H6O4
Formula Wt.

413.49
Chemical Name

3-[2-(Dimethyl-amin)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate; GR-43175C
IUPAC Name

butanedioic acid;1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N- methylmethanesulfonamide
Melting Point

165-166°C
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S8151 MSDS PDF
Info Sheet

S8151 Info Sheet PDF

References

Blumenfeld A, Gennings C, Cady R. Pharmacological synergy: the next frontier on therapeutic advancement for migraine. Headache. 2012 Apr;52(4):636-47. PMID: 22221151.

Loyd DR, Weiss G, Henry MA, et al. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain. 2011 Oct;152(10):2267-76. PMID: 21737202.

Muñoz-Islas E, Lozano-Cuenca J, González-Hernández A, et al. Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Eur J Pharmacol. 2009 Aug 1;615(1-3):133-8. PMID: 19460365.

Moro E, Crema F, De Ponti F, et al. Triptans and gastric accommodation: pharmacological and therapeutic aspects. Dig Liver Dis. 2004 Jan;36(1):85-92. PMID: 14971822.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1849

    Temozolomide

    Imidazotetrazine, DNA alkylator.

    ≥98%
  • D5612

    2-n-Dodecylfuran

    Furan derivative.

    ≥98%
  • C104762

    CCT-245737

    CHK1 inhibitor.

    ≥98%
  • S8013

    [Tyr8]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • E6994

    Erythromycin

    Macrolide; protein translation inhibitor, mamma...

    ≥94%
  • A5315

    Deoxyandrographolide

    Labdane diterpene found in Andrographolis; cNOS...

    ≥98%
  • K0276

    Katacalcin

    Peptide found in crustaceans; PKA activator.

    ≥95%
  • H9711

    (Z)-4-Hydroxytamoxifen

    SERM.

    ≥98%
  • M9367

    Myricetin

    Flavonol found in fruits and vegetables; COMT i...

    ≥98%
  • P2919

    L-Phenylalaninol

    Non-essential amino acid alcohol.

    ≥98%
  • N800000

    NU-2058

    CDK1/2 inhibitor.

    ≥98%
  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • Z7477

    ZSTK474

    PI3K inhibitor.

    ≥98%
  • B5871

    Bortezomib

    Proteasome inhibitor.

    ≥98%
  • N3474

    Nisoldipine

    Calcium channel blocker.

    ≥98%
  • R5745

    Rolipram

    Anxiolytic-like agent that stimulates angiogene...

    ≥98%
  • N3478

    Nitrendipine

    Calcium channel blocker.

    ≥98%
  • B4976

    BMS-794833

    MET, VEGFR2, Ron, Axl, FLT3 inhibitor.

    ≥98%
  • P7628

    Parathyroid Hormone-Related Protein (1-34), human/rat

    Endogenous peptide hormone, increases extracell...

    ≥95%
  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%