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Teniposide is a podophyllotoxin derivative that inhibits topoisomerase II and exhibits anticancer chemotherapeutic activity. Teniposide induces single stranded and double stranded DNA breaks and is clinically used to treat acute lymphocytic leukemia (ALL).
| Cas No. | 29767-20-2 |
|---|---|
| Purity | ≥97% |
| Formula | C32H32O13S |
| Formula Wt. | 656.66 |
| Chemical Name | [5R-[5α,5aβ,8aα,9β-(R*)]]-5,8,8a,9-Tetrahydro-5-(4- hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienyl- methylene)-β-D-glucopyranosyl]oxyfuro[3',4':6,7]- naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
| IUPAC Name | (5S,5aR,8aR,9R)-5-[[(4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4, 4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3, 5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1, 3]benzodioxol-8-one |
| Synonym | ETP, Vehem-Sandox, Vumon |
| Melting Point | 242-246°C |
| Solubility | Soluble in acetone or dimethylformamide. |
| Appearance | A white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
You Y. Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents. Curr Pharm Des. 2005;11(13):1695-717. PMID: 15892669.
Han YH, Austin MJ, Pommier Y, et al. Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro. J Mol Biol. 1993 Jan 5;229(1):52-66. PMID: 8380617.