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Terazosin Hydrochloride Dihydrate

Terazosin Hydrochloride Dihydrate

Product ID T1670
Cas No. 70024-40-7
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $97.10 In stock
250 mg $385.00 In stock
1 g $1,127.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Terazosin is a quinazoline compound that inhibits α1-adrenergic receptors, exhibiting antihypertensive, anti-metastatic, and anticancer activities. Terazosin is clinically used to treat benign prostatic hyperplasia (BPH) and hypertension. In prostate cells, terazosin increases activation of caspase 3 and induces apoptosis. In prostate cancer cells, this compound induces apoptosis and inhibits cellular proliferation, invasion, and migration.

 

Product Info

Cas No.

70024-40-7

Purity

≥98%

Formula

C19H25N5O4 • HCl • 2H2O

Formula Wt.

459.93

Chemical Name

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2- furoyl)piperazine monohydrochloride dihydrate

IUPAC Name

[4-(4-amino-6, 7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone; hydron;chloride;dihydrate

Synonym

Heitrin, Hytracin, Hytrin, Hytrinex, Itrin, Urodie, Vasocard

Melting Point

271-274°C

Solubility

Soluble in water (<1 mg/mL), DMSO (25 mg/mL), ethanol (<1 mg/mL), methanol, chloroform.

Appearance

A White to off White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1670 MSDS PDF

Info Sheet

T1670 Info Sheet PDF

References

Oelke M, Gericke A, Michel MC. Cardiovascular and ocular safety of α1-adrenoceptor antagonists in the treatment of male lower urinary tract symptoms. Expert Opin Drug Saf. 2014 Sep;13(9):1187-97. PMID: 25073735.

Papadopoulos G, Vlachodimitropoulos D, Kyroudi A, et al. Terazosin treatment induces caspase-3 expression in the rat ventral prostate. J Clin Med Res. 2013 Apr;5(2):127-31. PMID: 23518907.

Tahmatzopoulos A, Rowland RG, Kyprianou N. The role of alpha-blockers in the management of prostate cancer. Expert Opin Pharmacother. 2004 Jun;5(6):1279-85. PMID: 15163273.

Tomoda F, Takata M, Yoshida K, et al. Hemodynamic and endocrinological effects of a new selective alpha 1-blocking agent, terazosin, in patients with essential hypertension. Results of long-term treatment. Am J Hypertens. 1989 Nov;2(11 Pt 1):834-9. PMID: 2574044.

Custom Order

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