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Tivozanib

Tivozanib

Product ID T3585
Cas No. 475108-18-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $153.10 In stock
10 mg $236.90 In stock
25 mg $501.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tivozanib is an anticancer chemotherapeutic and anti-angiogenic compound that inhibits VEGFR1/2/3, c-Kit, and PDGFR. Tivozanib is currently in clinical trials as a potential treatment for renal cell carcinoma. The antiangiogenic activity of tivozanib is exhibited by its ability to suppress development of choroidal neovascular (CNV) lesions and also to regress established CNV in animal models.

Product Info

Cas No.

475108-18-0

Purity

≥98%

Formula

C22H19ClN4O5

Formula Wt.

454.86

Chemical Name

1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1, 2-oxazol-3-yl)urea

IUPAC Name

1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1, 2-oxazol-3-yl)urea

Synonym

AV-951

Appearance

Gray powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T3585 MSDS PDF

Info Sheet

T3585 Info Sheet PDF

References

Cowey CL. Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma. Drug Des Devel Ther. 2013 Jun 21;7:519-27. PMID: 23818763.

Hepgur M, Sadeghi S, Dorff TB, et al. Tivozanib in the treatment of renal cell carcinoma. Biologics. 2013;7:139-48. PMID: 23788831.

Kang S, Roh YJ, Kim IB. Antiangiogenic effects of tivozanib, an oral VEGF receptor tyrosine kinase inhibitor, on experimental choroidal neovascularization in mice. Exp Eye Res. 2013 Jul;112:125-33. PMID: 23701975.

Custom Order

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