LKT Labs

Biochemicals for Life Science Research

Tolfenamic Acid

Tolfenamic Acid

Product ID T5846
Cas No. 13710-19-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $72.00 In stock
25 g $245.00 In stock
50 g $378.00 In stock
Bulk Quote

Quicklinks

Description

Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and anticancer chemotherapeutic activities; it inhibits COX-1 and COX-2. Tolfenamic acid inhibits leukotriene B4 (LTB4) production, degranulation, and migration in polymorphonuclear leukocytes. Tolfenamic acid also downregulates expression of cyclin D1, increases ER stress, and induces apoptosis in colorectal cancer cells, inhibiting tumor growth in vivo. Additionally, tolfenamic acid also decreases expression of VEGF, VEGFR1, HGFR/c-MET, survivin, Bcl-2, and Sp proteins in cellular models of colorectal cancer.

Product Info

Cas No.

13710-19-5
Purity

≥98%
Formula

C14H12ClNO2
Formula Wt.

261.70
Chemical Name

2-[(3-Chloro-2-methylphenyl)amino]benzoic acid
IUPAC Name

2-(3-chloro-2-methylanilino)benzoic acid
Synonym

Clotam, Tolfedine, Tolfine
Melting Point

207-207.5°C
Solubility

Slightly soluble in water; freely sol in buffers with pH >8.2
Appearance

Off White Crystal Powder, Odorless

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5846 MSDS PDF
Info Sheet

T5846 Info Sheet PDF

References

Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Mol Carcinog. 2014 Feb;53 Suppl 1:E53-61. PMID: 23670891.

Zhang X, Lee SH, Min KW, et al. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev Res (Phila). 2013 Dec;6(12):1337-47. PMID: 24104354.

Kankaanranta H, Moilanen E, Vapaatalo H. Comparison of in vitro effects of flunixin and tolfenamic acid on human leukocyte and platelet functions. Inflammation. 1993 Aug;17(4):417-25. PMID: 8406686.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • G3356

    Ginkgolide AB

    Mixture of terpene lactones found in Ginkgo.

    ≥98%
  • T5946

    Toltrazuril

    Coccidiostat; mitochondrial respiration inhibit...

    ≥98%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • D183734

    7-O-Desmethyl Rapamycin

    Rapamycin impurity

    ≥85%
  • B030962

    BAY-1251152

    Inhibitor of PTEFb/CDK9.

    ≥98%
  • E0003

    E64-d

    Cathepsin inhibitor.

    ≥97%
  • G7440

    GSK-1120212

    MEK1/2 inhibitor.

    ≥98%
  • P6852

    Propafenone Hydrochloride

    β-adrenergic antagonist, Kv1.4 and K2P2 K+ cha...

    ≥98%
  • D0375

    Dasatinib Monohydrate

    Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...

    ≥98%
  • G4662

    GLPG-0634

    JAK1 inhibitor.

    ≥98%
  • I0482

    S-(+)-Ibuprofen

    Optically active isomer of ibuprofen, NSAID; CO...

    ≥98%
  • R5992

    Roxithromycin

    Macrolide; protein synthesis inhibitor.

    ≥96%
  • C2965

    Chromium Picolinate

    Used to prevent chromium deficiency and to decr...

    ≥98%
  • E6993

    Erythromycin Resistance Peptide MRLFV

    Peptide, confers resistance against macrolide a...

    ≥95%
  • B5074

    BMS-599626

    EGFR, VEGFR inhibitor.

    ≥98%
  • G733409

    GSK-2982772

    RIP1 inhibitor.

    ≥98%
  • E5211

    Endomorphin-2

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • S4932

    SMI-4a

    Thiazolidine; Pim kinase inhibitor.

    ≥99%
  • P0092

    Paclitaxel, from Taxus yunnanensis

    Diterpene found in Taxus yunnanensis; microtubu...

    ≥98%