• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tolfenamic Acid

Tolfenamic Acid

Product ID T5846
Cas No. 13710-19-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $71.50 In stock
25 g $245.30 In stock
50 g $377.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and anticancer chemotherapeutic activities; it inhibits COX-1 and COX-2. Tolfenamic acid inhibits leukotriene B4 (LTB4) production, degranulation, and migration in polymorphonuclear leukocytes. Tolfenamic acid also downregulates expression of cyclin D1, increases ER stress, and induces apoptosis in colorectal cancer cells, inhibiting tumor growth in vivo. Additionally, tolfenamic acid also decreases expression of VEGF, VEGFR1, HGFR/c-MET, survivin, Bcl-2, and Sp proteins in cellular models of colorectal cancer.

Product Info

Cas No.

13710-19-5

Purity

≥98%

Formula

C14H12ClNO2

Formula Wt.

261.70

Chemical Name

2-[(3-Chloro-2-methylphenyl)amino]benzoic acid

IUPAC Name

2-(3-chloro-2-methylanilino)benzoic acid

Synonym

Clotam, Tolfedine, Tolfine

Melting Point

207-207.5°C

Solubility

Slightly soluble in water; freely sol in buffers with pH >8.2

Appearance

Off White Crystal Powder, Odorless

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5846 MSDS PDF

Info Sheet

T5846 Info Sheet PDF

References

Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Mol Carcinog. 2014 Feb;53 Suppl 1:E53-61. PMID: 23670891.

Zhang X, Lee SH, Min KW, et al. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev Res (Phila). 2013 Dec;6(12):1337-47. PMID: 24104354.

Kankaanranta H, Moilanen E, Vapaatalo H. Comparison of in vitro effects of flunixin and tolfenamic acid on human leukocyte and platelet functions. Inflammation. 1993 Aug;17(4):417-25. PMID: 8406686.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R5874

    Rosmarinic Acid

    Caffeic acid ester found in Melissa, Salvia, an...

    ≥98%
  • N5669

    Nordihydroguaiaretic Acid

    Phenol found in the creosote bush; 5-lipoxygena...

    ≥99%
  • U8000

    U-74389G

    Antioxidant shown to improve renal function.

    ≥95%
  • D6108

    1,4-DPCA

    Prolyl hydroxylase inhibitor.  
    ≥98%
  • N0123

    Naftopidil

    α1-adrenergic antagonist.

    ≥98%
  • M0009

    Macitentan

    ET-A/B antagonist.

    ≥99%
  • N5766

    L-(-)-Norepinephrine Bitartrate Monohydrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • S8251

    Sulfluramid

    Perfluorinated insecticide.

    ≥95%
  • G016499

    2’,3’-cGAMP Sodium Salt

    Agonist of STING.

    ≥99%
  • C0274

    Caspofungin Diacetate

    Lipopeptide; 1,3-β-Glucan synthase inhibitor.<...

    ≥95%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • C9662

    Cyproterone Acetate

    Steroid; AR antagonist.

    ≥98%
  • S7769

    Streptomycin Sulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • T6935

    Trimebutine Base

    BK K+ channel and L-type Ca2+ channel blocker.<...

    ≥97%
  • E4417

    Eledoisin Related Peptide

    Peptide, substance P analog; NK agonist.

    ≥95%
  • T5944

    Tolmetin Sodium

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • I0801

    IC261

    Casein kinase 1 inhibitor.

    ≥98%
  • M0125

    Magnolol

    Lignan found in Magnolia; GABA-A potentiator.

    ≥98%
  • T0299

    Tazobactam Sodium

    β-lactamase inhibitor.

    ≥98%
  • G1749

    Gemfibrozil

    Fibrate; PPARα agonist, enoyl-CoA reductase in...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only