LKT Labs

Biochemicals for Life Science Research

Tolfenamic Acid

Tolfenamic Acid

Product ID T5846
Cas No. 13710-19-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $72.00 In stock
25 g $245.00 In stock
50 g $378.00 In stock
Bulk Quote

Quicklinks

Description

Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and anticancer chemotherapeutic activities; it inhibits COX-1 and COX-2. Tolfenamic acid inhibits leukotriene B4 (LTB4) production, degranulation, and migration in polymorphonuclear leukocytes. Tolfenamic acid also downregulates expression of cyclin D1, increases ER stress, and induces apoptosis in colorectal cancer cells, inhibiting tumor growth in vivo. Additionally, tolfenamic acid also decreases expression of VEGF, VEGFR1, HGFR/c-MET, survivin, Bcl-2, and Sp proteins in cellular models of colorectal cancer.

Product Info

Cas No.

13710-19-5
Purity

≥98%
Formula

C14H12ClNO2
Formula Wt.

261.70
Chemical Name

2-[(3-Chloro-2-methylphenyl)amino]benzoic acid
IUPAC Name

2-(3-chloro-2-methylanilino)benzoic acid
Synonym

Clotam, Tolfedine, Tolfine
Melting Point

207-207.5°C
Solubility

Slightly soluble in water; freely sol in buffers with pH >8.2
Appearance

Off White Crystal Powder, Odorless

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5846 MSDS PDF
Info Sheet

T5846 Info Sheet PDF

References

Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Mol Carcinog. 2014 Feb;53 Suppl 1:E53-61. PMID: 23670891.

Zhang X, Lee SH, Min KW, et al. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev Res (Phila). 2013 Dec;6(12):1337-47. PMID: 24104354.

Kankaanranta H, Moilanen E, Vapaatalo H. Comparison of in vitro effects of flunixin and tolfenamic acid on human leukocyte and platelet functions. Inflammation. 1993 Aug;17(4):417-25. PMID: 8406686.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B9200

    BX-795

    PDK1 inhibitor.

    ≥98%
  • S8007

    Substance P (1-7)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • L8008

    D-Luciferin, firefly, Free Acid

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • G4518

    Glucaric Acid Calcium Tetrahydrate

    Oxidized non-cylic hexose sugar.

    ≥98%
  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • K0038

    Kahweol Oleate

    Diterpene found in coffee beans.

    ≥98%
  • C0173

    Carmustine

    Nitrosourea, DNA alkylator.

    ≥98%
  • O0830

    Ochratoxin B

    Non-chlorinated analogue of the mycotoxin Ochra...

    ≥99%
  • N3350

    Nimorazole

    Nitroimidazole; hypoxic modifier and radiosensi...

    ≥98%
  • A480020

    (R,S)-AM 1241

    Cannabinoid receptor 2 selective agonist.

    ≥96%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B0396

    BAY80-6946

    p110α PI3K inhibitor.

    ≥98%
  • G4597

    18β-Glycyrrhetinic Acid

    Triterpene glycoside found in Glycyrrhiza; 15-H...

    ≥98%
  • T6803

    Trandolapril

    ACE inhibitor.

    ≥98%
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%
  • T1020

    n-Butyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • B0397

    BAY80-6946 Hydrochloride

    pan-PI3K inhibitor

    ≥98%
  • E5569

    Enramycin B

    Polypeptide; peptidoglycan inhibitor.

    ≥83%
  • D1774

    Desloratadine

    Loratadine metabolite; FIASMA, histamine H1 ant...

    ≥97%