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Topotecan Hydrochloride

Topotecan Hydrochloride

Product ID T5761
Cas No. 119413-54-6
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $92.00 In stock
10 mg $110.50 In stock
50 mg $188.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Topotecan is an anticancer chemotherapeutic compound that inhibits topoisomerase I and is clinically used to treat various cancers. Topotecan induces apoptosis in retinocytoma cells and ovarian cancer cells.

Product Info

Cas No.

119413-54-6

Purity

≥97%

Formula

C23H25N3O5 • HCl

Formula Wt.

457.91

Chemical Name

(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]- quinoline-3,14(4H,12H)-dione hydrochloride

IUPAC Name

(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride

Synonym

Hycamtin, NSC-609669, SKF-104864A

Melting Point

213-218°C(dec.)

Solubility

Soluble in methanol, water (92 mg/mL at 25 °C), DMSO (92 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and 1: 1 solution of DMSO: PBS (pH 7.2, ~0.5 mg/mL).

Appearance

Pale Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5761 MSDS PDF

Info Sheet

T5761 Info Sheet PDF

References

Attia SM, Ahmad SF, Abd-Ellah MF, et al. Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 2013 Dec;62:470-4. PMID: 24036143.

Zhang M, Shan BE, Yuan NF, et al. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chin Med J (Engl). 2013 Jan;126(2):340-4. PMID: 23324287.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Sonabend AM, Stuart RM, Yun J, et al. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol. 2011 Aug;13(8):886-893. PMID: 21750007.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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