• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Topotecan Hydrochloride

Topotecan Hydrochloride

Product ID T5761
Cas No. 119413-54-6
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $92.00 In stock
10 mg $110.50 In stock
50 mg $188.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Topotecan is an anticancer chemotherapeutic compound that inhibits topoisomerase I and is clinically used to treat various cancers. Topotecan induces apoptosis in retinocytoma cells and ovarian cancer cells.

Product Info

Cas No.

119413-54-6

Purity

≥97%

Formula

C23H25N3O5 • HCl

Formula Wt.

457.91

Chemical Name

(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]- quinoline-3,14(4H,12H)-dione hydrochloride

IUPAC Name

(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride

Synonym

Hycamtin, NSC-609669, SKF-104864A

Melting Point

213-218°C(dec.)

Solubility

Soluble in methanol, water (92 mg/mL at 25 °C), DMSO (92 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and 1: 1 solution of DMSO: PBS (pH 7.2, ~0.5 mg/mL).

Appearance

Pale Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5761 MSDS PDF

Info Sheet

T5761 Info Sheet PDF

References

Attia SM, Ahmad SF, Abd-Ellah MF, et al. Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 2013 Dec;62:470-4. PMID: 24036143.

Zhang M, Shan BE, Yuan NF, et al. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chin Med J (Engl). 2013 Jan;126(2):340-4. PMID: 23324287.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Sonabend AM, Stuart RM, Yun J, et al. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol. 2011 Aug;13(8):886-893. PMID: 21750007.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H9763

    Hypoxanthine

    Endogenous purine derivative of xanthine.

    ≥98%
  • Z161022

    α-Zearalanol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • T286163

    Theaflavin-3,3’-digallate

    Polyphenolic compound present in black tea.

    ≥98%
  • E5477

    Entinostat

    Benzamide; HDAC1 inhibitor.

    ≥98%
  • K0552

    Kb NB 77-78

    CID-797718 analog; potential PKD1 binding agent...

    ≥98%
  • A1368

    Adrenomedullin (1-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • D1695

    Dexamethasone Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%
  • R3013

    Recombinant TpN 44.50 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • A4523

    Alfuzosin Hydrochloride

    α1-adrenergic antagonist.

    ≥97%
  • V9201

    VX-11e

    ERK2 inhibitor, potential AurKA, GSK3, CDK2, FL...

    ≥98%
  • M568268

    Mogroside IV

    Triterpenoid

    ≥98%
  • W3576

    Withaferin A

    Steroid lactone produced by Withania somnifera;...

    ≥98%
  • I7557

    1-Isothiocyanato-6-(methylsulfonyl)-hexane

    Synthetic ITC, erysolin analog.

    ≥98%
  • A7208

    Ascomycin

    FK506 analog; calcineurin inhibitor.

    ≥98%
  • T5604

    Tobramycin, Free Base

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • A4497

    Alyssin Sulfone

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • B3210

    R-Bicalutamide

    AR antagonist.

    ≥98%
  • U6860

    Urocortin III, mouse

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • I458579

    Iloprost

    Prostacyclin analog

    ≥98%
  • E5178

    Emtricitabine

    Nucleoside (cytidine) analog; RT and telomerase...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only