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Triamcinolone is a synthetic steroid that downregulates expression of VEGF and exhibits anti-inflammatory and anti-angiogenic activities; it is an agonist at the glucocorticoid receptor. Triamcinolone is clinically used to treat retinal edema and other ocular pathologies and may cause ocular hypertension.
| Cas No. | 76-25-5 |
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| Purity | ≥98% |
| Formula | C24H31FO6 |
| Formula Wt. | 434.50 |
| Chemical Name | 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone |
| IUPAC Name | (1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one |
| Synonym | Adcortyl, AristocortR, Delphicort, Extracort, NasacortR |
| Melting Point | 292-294°C |
| Solubility | Sparingly soluble in methanol, acetone or ethyl acetate. |
| Appearance | White or almost white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhou H, Yang L, Li H, et al. Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells. Int J Nanomedicine. 2012;7:4649-60. PMID: 22942646.
McAllister IL, Vijayasekaran S, Chen SD, et al. Effect of triamcinolone acetonide on vascular endothelial growth factor and occludin levels in branch retinal vein occlusion. Am J Ophthalmol. 2009 May;147(5):838-46, 846.e1-2. PMID: 19211093.
Mizuno D, Matsubara A, Ogura Y. Effect of posterior sub-tenon administration of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation after panretinal photocoagulation. Invest Ophthalmol Vis Sci. 2008 May;49(5):2127-33. PMID: 18436845.