• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tropisetron Hydrochloride

Tropisetron Hydrochloride

Product ID T7156
Cas No. 105826-92-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $104.10 In stock
50 mg $295.50 In stock
100 mg $433.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tropisetron is an antagonist at 5-HT3 receptors and partial agonist at α7 nicotinic acetylcholine receptors (nAChRs) that exhibits antiemetic, analgesic, anti-inflammatory, nephroprotective, neuroprotective, and anti-fibrotic activities. In animal models of nephrotoxicity, tropisetron decreases levels of TNF-α, IL-1β, and iNOS and improves renal pathology. Additionally, tropisetron increases survival of glutamatergic neurons by decreasing levels of p38 MAPK and inducing NMDA receptor internalization in vitro. Tropisetron also inhibits collagen synthesis and fibrosis in animal models of scleroderma.

Product Info

Cas No.

105826-92-4

Purity

≥98%

Formula

C17H20N2O2 • HCl

Formula Wt.

320.82

Chemical Name

1H-Indole-3-carboxylic acid (3-endo)-8-methyl- 8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride

IUPAC Name

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 1H-indole-3-carboxylate;hydrochloride

Synonym

Navoban, Novaban

Melting Point

283-285°C (dec)

Solubility

Soluble in water.

Appearance

A White Crystalline Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T7156 MSDS PDF

Info Sheet

T7156 Info Sheet PDF

References

Zirak MR, Rahimian R, Ghazi-Khansari M, et al. Tropisetron attenuates cisplatin-induced nephrotoxicity in mice. Eur J Pharmacol. 2014 Jun 4. [Epub ahead of print]. PMID: 24905858.

Swartz MM, Linn DM, Linn CL. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21. PMID: 23727438.

Stegemann A, Sindrilaru A, Eckes B, et al. Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. Arthritis Rheum. 2013 Mar;65(3):792-804. PMID: 23440693.

Bandschapp O, Filitz J, Urwyler A, et al. Tropisetron blocks analgesic action of acetaminophen: a human pain model study. Pain. 2011 Jun;152(6):1304-10. PMID: 21420788.

Hsu ES. A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. Am J Ther. 2010 Sep-Oct;17(5):476-86. PMID: 20844345.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O9497

    Oxytocin

    Endogenous neuropeptide hormone, involved in so...

    ≥95%
  • T3584

    Tivantinib

    MET and GSK-3α/β inhibitor.

    ≥98%
  • R3312

    Ridaifen A Dihydrochloride

    Tamoxifen derivative; potential proteasome inhi...

    ≥98%
  • T1675

    Teriparatide Acetate

    Synthetic peptide hormone, PTH analog; PTH1R ag...

    ≥95%
  • P3600

    PJ34 Hydrochloride

    PARP inhibitor; potential Pim1 inhibitor.

    ≥95%
  • P2922

    Phenylhexyl Isothiocyanate

    ITC found in cruciferous vegetables; HDAC inhib...

    ≥98%
  • M1778

    S-(+)-α−Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.

    ≥98%
  • T0140

    TAK-632

    RAF inhibitor.

    ≥99%
  • N2400

    NG-52

    Purine, purvalenol A analog; CDK2, Cdc28p, Pho8...

    ≥98%
  • C4756

    Cloxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • F1895

    Fexofenadine Hydrochloride

    Histamine H1 antagonist.

    ≥98%
  • C691325

    Cridanimod

    STING agonist

    ≥99%
  • A4805

    Amastatin Hydrochloride Hydrate

    Aminopeptidase inhibitor.

    ≥98%
  • B3203

    Biapenem

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%
  • A5034

    4-Aminosalicylic Sodium Dihydrate

    Dihydrofolate reductase inhibitor.

    ≥98%
  • V3212

    Vidarabine

    Nucleoside (adenosine) analog; viral DNA polyme...

    ≥98%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • A4002

    AK-7

    SIRT2 inhibitor.

    ≥98%
  • T3100

    Thyrotropin-releasing Hormone

    Endogenous tripeptide, involved in HPA signalin...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only