Vidarabine Monophosphate

Name: Vidarabine Monophosphate
SKU: V3213
Availability: InStock

Product ID V3213

Cas No. 29984-33-6

Purity ≥98.0%

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Description

Vidarabine is a long-acting antiviral originally found in the marine sponge Tethyra crypta. Vidarabine is an adenosine analog in which the D-ribose constituent is replaced by D-arabinose, preventing formation of phosphodiester bridges upon incorporation into DNA. This compound is a substrate for and inhibitor of viral DNA polymerase and may also inhibit ribonucleotide reductase. Vidarabine is used to treat subjects with severe chronic Epstein-Barr virus, herpes simplex virus, or human papilloma virus, as well as immunocompromised patients with adenovirus-induced hemorrhagic cystitis.

Product Info

Cas No.	29984-33-6
Purity	≥98.0%
Formula	C₁₀H₁₄N₅O₇P
Formula Wt.	347.22
Chemical Name	9-(5-O-Phosphono-beta-D-arabinofuranosyl)adenine
IUPAC Name	[(2R,3S,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Synonym	Ara-AMP
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	V3213 MSDS PDF
Info Sheet	V3213 Info Sheet PDF

References

Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

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Vidarabine Monophosphate

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Description

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