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Hygromycin B is an antibiotic that also displays antiviral activity. Hygromycin binds the 30S ribosomal subunit, inhibiting protein and RNA synthesis of bacteria or viruses; it induces misreadings at multiple steps in protein translation and suppresses translocation. In animal models, hygromycin B allows translation to occur but prevents formation of viral antigen by Leishmania and, separately, prevents infection by murine hepatitis virus.
| Cas No. | 31282-04-9 |
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| Purity | ≥95.0% |
| Formula | C20H37N3O13 |
| Formula Wt. | 527.52 |
| Chemical Name | (2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol |
| IUPAC Name | 4-[3-amino-2, 6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-(1-amino-2-hydroxyethyl)-6- (hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2, 2'-oxane]-3',4',5',7-tetrol |
| Synonym | Hygrovetine |
| Appearance | Buff Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.
Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.
Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.