LKT Labs

Biochemicals for Life Science Research

Bleomycin Sulfate

Bleomycin Sulfate

Product ID B4518
Cas No. 9041-93-4
Purity ≥90%
Product Unit SizeCostQuantityStock
5 mg $200.10 In stock
10 mg $275.50 In stock
25 mg $561.40 In stock
100 mg $1,735.80 In stock
Bulk Quote

Quicklinks

Description

This product is a mixture of bleomycin sulfate salts; bleomycin A2 is pictured. Bleomycin is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin A5 is clinically used to treat lymphomas, squamous cell carcinomas, and testicular cancer. Additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. Bleomycin A2 inhibits viral reproduction of human papilloma virus. Bleomycin A2 also cleaves DNA at 5’-GT sequences (including in telomeres) and induces tRNA cleavage. Bleomycin may also inhibit thioredoxin reductase.

Product Info

Cas No.

9041-93-4
Purity

≥90%
Formula

C55H84N17O21S3 • H2SO4

Formula Wt.

1512.63
IUPAC Name

3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
Synonym

Blenoxane, Blexane

Melting Point

71°C

Solubility

Soluble in water ( 20 mg/mL), DMSO (100 mg/mL), methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B4518 MSDS PDF
Info Sheet

B4518 Info Sheet PDF

References

Ramírez-Fort MK, Au SC, Javed SA, et al. Management of cutaneous human papillomavirus infection: pharmacotherapies. Curr Probl Dermatol. 2014;45:175-85. PMID: 24643186.

Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

Nguyen HT, Murray V. The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells. J Biol Inorg Chem. 2012 Dec;17(8):1209-15. PMID: 22961398.

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

Abraham AT, Lin JJ, Newton DL, et al. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 2003 Jan;10(1):45-52. PMID: 12573697.

Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 2000 Jan;63(1):158-68. PMID: 10650103.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B0246

    Balofloxacin Dihydrate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • S336507

    Simufilam Dihydrochloride

    Unlikely to reverse Alzheimer’s

    ≥98%
  • W0272

    S-(−)-Warfarin >99%ee

    Coumarin, more potent isomer; VKORC1 inhibitor....

    ≥99%
  • C0270

    Carbamazepine

    GABA potentiator, voltage-gated Na+ and ATP-sen...

    ≥98%
  • T0103

    Taxol Side Chain Diol

    Side chain attached to various taxanes.

    ≥98%
  • O1078

    Octreotide Acetate

    Somatostatin analog, peptide; somatostatin agon...

    ≥95%
  • E846182

    Everolimus EP Impurity E

    Impurity of everolimus

    ≥80%
  • A7309

    Ascorbyl Palmitate

    Fat-soluble vitamin C derivative.

    ≥95%
  • A016495

    5-Aminopyrimidine

    Building block

    ≥98%
  • F8147

    Fulvestrant

    Induces ER degradation.

    ≥98%
  • B6807

    [Des-Arg9]-Bradykinin

    Natriuretic, vasodilatory peptide, bradykinin a...

    ≥95%
  • I0800

    IC-87114

    p110δ PI3K inhibitor.

    ≥98%
  • T2800

    Thalidomide

    Immunomodulator; teratogen.

    ≥98%
  • R2713

    Recombinant HCV-NS4 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • M0272

    Mastoparan 7

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • C0029

    Cafestol Oleate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • W0269

    (±)-Warfarin

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • W9602

    WY-14643

    A peroxisome proliferator-activated receptor ag...

    ≥98%
  • O1177

    n-Octyl-3,4-Dimethylcaffeate

    Methylated derivative of n-octyl-caffeate.

    ≥98%