LKT Labs

Biochemicals for Life Science Research

Bleomycin Sulfate

Bleomycin Sulfate

Product ID B4518
Cas No. 9041-93-4
Purity ≥90%
Product Unit SizeCostQuantityStock
5 mg $200.10 In stock
10 mg $275.50 In stock
25 mg $561.40 In stock
100 mg $1,735.80 In stock
Bulk Quote

Quicklinks

Description

This product is a mixture of bleomycin sulfate salts; bleomycin A2 is pictured. Bleomycin is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin A5 is clinically used to treat lymphomas, squamous cell carcinomas, and testicular cancer. Additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. Bleomycin A2 inhibits viral reproduction of human papilloma virus. Bleomycin A2 also cleaves DNA at 5’-GT sequences (including in telomeres) and induces tRNA cleavage. Bleomycin may also inhibit thioredoxin reductase.

Product Info

Cas No.

9041-93-4
Purity

≥90%
Formula

C55H84N17O21S3 • H2SO4

Formula Wt.

1512.63
IUPAC Name

3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
Synonym

Blenoxane, Blexane

Melting Point

71°C

Solubility

Soluble in water ( 20 mg/mL), DMSO (100 mg/mL), methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B4518 MSDS PDF
Info Sheet

B4518 Info Sheet PDF

References

Ramírez-Fort MK, Au SC, Javed SA, et al. Management of cutaneous human papillomavirus infection: pharmacotherapies. Curr Probl Dermatol. 2014;45:175-85. PMID: 24643186.

Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

Nguyen HT, Murray V. The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells. J Biol Inorg Chem. 2012 Dec;17(8):1209-15. PMID: 22961398.

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

Abraham AT, Lin JJ, Newton DL, et al. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 2003 Jan;10(1):45-52. PMID: 12573697.

Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 2000 Jan;63(1):158-68. PMID: 10650103.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D0025

    DAMGO

    Synthetic peptice; μOR agonist.

    ≥95%
  • S0368

    Sarcophine

    Cembranoid diterpene found in Sarcophyton glauc...

    ≥98%
  • G720009

    GS-9901

    Selective inhibitor of the delta isoform of PI3...

    ≥99%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • B1545

    Benzalkonium Bromide

    Quaternary ammonium cationic surfactant, dissoc...

    ≥95%
  • V2792

    VGX-1027

    TLR4 inhibitor.

    ≥98%
  • G3356

    Ginkgolide AB

    Mixture of terpene lactones found in Ginkgo.

    ≥98%
  • D6108

    1,4-DPCA

    Prolyl hydroxylase inhibitor.

    ≥98%
  • E4416

    Eledoisin

    Peptide, substance P analog; NK agonist.

    ≥95%
  • R2400

    RG-108

    DNMT inhibitor.

    ≥98%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • C0366

    Carvedilol Phosphate Hemihydrate

    FIASMA; α1- and β1/2-adrenergic antagonist.

    ≥98%
  • C8070

    Curcumin, high purity

    Active compound found in turmeric; MST1 activat...

    ≥98%
  • O9458

    Oxolinic Acid

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • P0110

    (R)-P7C3-OMe

    Methoxy aminopropyl carbazole, neuroprotective....

    ≥98%
  • A145823

    ADU-S100 sodium salt

    Synthetic cyclic dinucleotide agonist of STING....

    ≥99%
  • Q8135

    Quinestrol

    Synthetic steroid hormone, estrogen analog, use...

    ≥98%
  • M1680

    5-Methoxyindole

    Core structure of melatonin; potential PPARγ a...

    ≥98%
  • G691343

    Griseofulvin

    Fungistatic

    ≥98%