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2-Hydroxyflutamide

2-Hydroxyflutamide

Product ID H9718
Cas No. 52806-53-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $142.90 In stock
25 mg $306.20 In stock
100 mg $918.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

2-Hydroxyflutamide is a non-steroidal anti-androgen that inhibits the androgen receptor. 2-Hydroxyflutamide exhibits anti-resorptive and anticancer activity. In osteoblasts, 2-hydroxyflutamide inhibits production of IL-6 and activation of NF-κB. In prostate cancer cells, this compound enhances the efficacy of other co-administered chemotherapeutics such as 5-fluorouracil.

Product Info

Cas No.

52806-53-8

Purity

≥98%

Formula

C11H11F3N2O4

Formula Wt.

292.21

Chemical Name

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

IUPAC Name

2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Synonym

Hydroxyniphtholide

Melting Point

125-130°C

Appearance

Yellow or off-white to tan powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9718 MSDS PDF

Info Sheet

H9718 Info Sheet PDF

References

Kawabata R, Oie S, Oka T, et al. Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells. Int J Oncol. 2011 Mar;38(3):665-76. PMID: 21243325.

Hofbauer LC, Ten RM, Khosla S. The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. J Bone Miner Res. 1999 Aug;14(8):1330-7. PMID: 10457265.

Furr BJ, Valcaccia B, Curry B, et al. ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J Endocrinol. 1987 Jun;113(3):R7-9. PMID: 3625091.

Custom Order

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