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2-Hydroxyflutamide is a non-steroidal anti-androgen that inhibits the androgen receptor. 2-Hydroxyflutamide exhibits anti-resorptive and anticancer activity. In osteoblasts, 2-hydroxyflutamide inhibits production of IL-6 and activation of NF-κB. In prostate cancer cells, this compound enhances the efficacy of other co-administered chemotherapeutics such as 5-fluorouracil.
| Cas No. | 52806-53-8 |
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| Purity | ≥98% |
| Formula | C11H11F3N2O4 |
| Formula Wt. | 292.21 |
| Chemical Name | 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| IUPAC Name | 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| Synonym | Hydroxyniphtholide |
| Melting Point | 125-130°C |
| Appearance | Yellow or off-white to tan powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kawabata R, Oie S, Oka T, et al. Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells. Int J Oncol. 2011 Mar;38(3):665-76. PMID: 21243325.
Hofbauer LC, Ten RM, Khosla S. The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. J Bone Miner Res. 1999 Aug;14(8):1330-7. PMID: 10457265.
Furr BJ, Valcaccia B, Curry B, et al. ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J Endocrinol. 1987 Jun;113(3):R7-9. PMID: 3625091.