Description
This compound is a derivative of cephalomannine, found in species of Taxus. Like other taxanes, this compound may inhibit DNA polymerase and microtubule depolymerization, exhibiting anticancer activity.
7-epi-Cephalomannine
Product ID T0118
Cas No. 150547-36-7
Purity ≥95%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 150547-36-7 |
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| Purity | ≥95% |
| Formula | C45H53NO14 |
| Formula Wt. | 831.9 |
| IUPAC Name | [(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4,12-diacetyloxy-1,9-dihydroxy-15-[(2R,3S)-2-hydroxy-3-[[(E)-2-methylbut-2-enoyl]amino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.
Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.
Pandey RC, Yankov LK, Poulev A, et al. Synthesis and separation of potential anticancer active dihalocephalomannine diastereomers from extracts of Taxus yunnanensis. J Nat Prod. 1998 Jan;61(1):57-63. PMID: 9461653.