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AS-703026

AS-703026

Product ID A7203
Cas No. 1236699-92-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $82.70 In stock
5 mg $155.00 In stock
25 mg $291.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AS-703026, pimasertib, is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. In vitro, AS-703026 inhibits proliferation of melanoma cells. In both in vitro and in vivo models of colorectal cancer containing WT Ras or mutant KRAS, AS-703026 inhibits growth of cells and also of tumors. Additionally, AS-703026 inhibits growth and survival of multiple myeloma cells by inducing activation of caspase 3, cleavage of poly(ADP)-ribose polymerase (PARP), and apoptosis; this compound suppresses tumor growth and decreases microvessel numbers in animal models as well.

Product Info

Cas No.

1236699-92-5

Purity

≥98%

Formula

C15H15FlN3O3

Formula Wt.

431.20

IUPAC Name

N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide

Synonym

MSC1936369B, Pimasertib

Solubility

DMSO 86 mg/mL (199.44 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7203 MSDS PDF

Info Sheet

A7203 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Park SJ, Hong SW, Moon JH, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8. PMID: 24051957.

Yoon J, Koo KH, Choi KY. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res. 2011 Jan 15;71(2):445-53. PMID: 21118963.

Kim K, Kong SY, Fulciniti M, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol. 2010 May;149(4):537-49. PMID: 20331454.

Custom Order

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