LKT Labs

Biochemicals for Life Science Research

AZD-1152-HQPA

Product ID A9714
Cas No. 722544-51-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $98.50 Please Inquire
5 mg $182.00 Please Inquire
10 mg $295.70 Please Inquire
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Description

AZD-1152-HQPA inhibits aurora kinases B and C (AurB, AurC), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for cancers with solid tumors. In acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) cells, AZD-1152-HQPA induces apoptosis, inhibiting proliferation. AZD-1152-HQPA also induces apoptosis in glioma cells, inhibiting proliferation in vitro and tumor growth in vivo.

Product Info

Cas No.

722544-51-6
Purity

≥98%
Formula

C26H30FN7O3
Formula Wt.

507.56
IUPAC Name

2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide
Synonym

AZD1152-HQPA
Solubility

DMSO 102 mg/mL (200.96 mM) Ethanol 3 mg/mL (5.91 mM) Water Insoluble
Appearance

Off-white Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A9714 MSDS PDF
Info Sheet

A9714 Info Sheet PDF

References

Hartsink-Segers SA, Zwaan CM, Exalto C, et al. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target. Leukemia. 2013 Mar;27(3):560-8. PMID: 22940834.

Diaz RJ, Golbourn B, Shekarforoush M, et al. Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. J Neurooncol. 2012 Jul;108(3):349-60. PMID: 22382783.

Boss DS, Witteveen PO, van der Sar J,et al. Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors. Ann Oncol. 2011 Feb;22(2):431-7. PMID: 20924078.

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