Description
Benztropine is an inhibitor of the dopamine transporter (DAT); it potentiates dopamine overflow in rat brain slices.
| Product Unit Size | Cost | Quantity | Stock |
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Benztropine is an inhibitor of the dopamine transporter (DAT); it potentiates dopamine overflow in rat brain slices.
| Cas No. | 132-17-2 |
|---|---|
| Purity | ≥99% |
| Formula | C21H25NO • CH4O3S |
| Formula Wt. | 403.53 |
| Chemical Name | 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonic acid |
| IUPAC Name | 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonic acid |
| Synonym | Cogentin mesylate |
| Solubility | Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ukairo OT, Bondi CD, Newman AH, et al. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther. 2005 Aug;314(2):575-83. PMID: 15879005.
Wieczorek WJ, Kruk ZL. A quantitative comparison on the effects of benztropine, cocaine and nomifensine on electrically evoked dopamine overflow and rate of re-uptake in the caudate putamen and nucleus accumbens in the rat brain slice. Brain Res. 1994 Sep 19;657(1-2):42-50. PMID: 7820642.
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