Description
Benztropine is an inhibitor of the dopamine transporter (DAT); it potentiates dopamine overflow in rat brain slices.
Benztropine Mesylate
Product ID B1955
Cas No. 132-17-2
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 132-17-2 |
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| Purity | ≥99% |
| Formula | C21H25NO • CH4O3S |
| Formula Wt. | 403.53 |
| Chemical Name | 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonic acid |
| IUPAC Name | 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonic acid |
| Synonym | Cogentin mesylate |
| Solubility | Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly). |
| Appearance | White Crystal Powder |
Shipping and Storage
| Store Temp | Ambient |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Ukairo OT, Bondi CD, Newman AH, et al. Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther. 2005 Aug;314(2):575-83. PMID: 15879005.
Wieczorek WJ, Kruk ZL. A quantitative comparison on the effects of benztropine, cocaine and nomifensine on electrically evoked dopamine overflow and rate of re-uptake in the caudate putamen and nucleus accumbens in the rat brain slice. Brain Res. 1994 Sep 19;657(1-2):42-50. PMID: 7820642.