Description
Bicuculline is a neuromodulatory GABA-A receptor antagonist used to study regional variation of GABA receptors and the role of GABA-A receptors in motor disorders, pain, seizure, nociception, anxiety, and memory. Through its inhibition of GABA-A receptors, bicuculline potentiates activation at NMDA receptors and produces membrane depolarization, inhibiting K+ conductance and prolonging Ca2+-dependent action potentials in neurons.
Specific rotation +130 (20 D, chloroform c=2)