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Bis(3,5-dibromosalicyl) Fumarate

Bis(3,5-dibromosalicyl) Fumarate

Product ID B3272
Cas No. 71337-53-6
Purity ≥91%
Product Unit SizeCostQuantityStock
100 mg $38.90 In stock
500 mg $136.50 In stock
1 g $195.30 In stock
5 g $392.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bis(3,5-dibromosalicyl) fumarate is an aspirin analog that is used to induce hemoglobin chain crosslinks at lysine residues. This compound is used to study hemoglobin function in research models and may be used to develop treatments for sickle-cell anemia. This compound may exhibit anti-inflammatory, analgesic, and antipyretic activities.

Product Info

Cas No.

71337-53-6

Purity

≥91%

Formula

C18H8O8Br4

Formula Wt.

671.87

Chemical Name

2-Butenedioic acid (E)-, bis(2,4-dibromo-6-carboxyphenyl) ester

IUPAC Name

3,5-dibromo-2-[(E)-4-(2, 4-dibromo-6-carboxyphenoxy)-4-oxobut-2-enoyl]oxybenzoic acid

Synonym

3,5-Dibromosalicyl-bis-fumarate, (E)-2,2'-(Fumaroylbis(oxy))bis(3,5-dibromobenzoic acid) CAS Number: 71337-53-6 Molecular Weight: 671.87 MDL number: MFCD03547939

Melting Point

225-228°C

Solubility

Slightly soluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B3272 MSDS PDF

Info Sheet

B3272 Info Sheet PDF

References

Macdonald VW, Motterlini R. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75. PMID: 7994376.

Thompson EB, Klotz IM. Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects. Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):381-8. PMID: 4023420.

Chatterjee R, Iwai Y, Walder RY, et al. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site. J Biol Chem. 1984 Dec 10;259(23):14863-73. PMID: 6501320.

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