• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Cambinol

Cambinol

Product ID C0048
Cas No. 14513-15-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $234.40 In stock
25 mg $972.40 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cambinol is an inhibitor of sirtuins, particularly sirtuin1. Cambinol exhibits anti-inflammatory and anticancer chemotherapeutic activities. In various cell lines, cambinol suppresses MAPK and MEK signaling and inhibits expression of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and IFN-γ. Additionally, cambinol improves survival of animal models of endotoxic shock and septic shock. In vitro, cambinol inhibits proliferation and increases differentiation and senescence in hepatocellular carcinoma cells. In vivo, cambinol inhibits xenograft growth in models of hepatocellular carcinoma and Burkitt’s lymphoma.

Product Info

Cas No.

14513-15-6

Purity

≥98%

Formula

C21H16N2O2S

Formula Wt.

360.43

IUPAC Name

5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one

Synonym

SIRT 1/2 inhibitor IV, SIRT1 Inhibitor II, NSC112546, SIRT2 Inhibitor VI.

Solubility

Soluble in DMSO (≥10 mg/ml), and ethanol (5 mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C0048 MSDS PDF

Info Sheet

C0048 Info Sheet PDF

References

Lugrin J, Ciarlo E, Santos A, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510. PMID: 23499872.

Portmann S, Fahrner R, Lechleiter A, et al. Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Mol Cancer Ther. 2013 Apr;12(4):499-508. PMID: 23339189.

Heltweg B, Gatbonton T, Schuler AD, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77. PMID: 16618762.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S3345

    Silymarin

    Flavonolignan mixture found in Silybum (milk th...

    ≥50% sylibin
  • T1644

    Telmisartan

    AT-II antagonist, PPARγ/δ modulator.

    ≥98%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • I7074

    Irsogladine Maleate

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • T3096

    Thymosin α-1

    Endogenous peptide fragment, immunostimulant; ...

    ≥95%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • R2811

    Recombinant HIV-1 gp-41

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • P2816

    S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate.

    ≥98%
  • T1844

    Telbivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • G3457

    Ginsenoside Re

    Triterpene saponin found in species of Panax; P...

    ≥98%
  • D1722

    Defactinib

    FAK inhibitor.

    ≥98%
  • A6982

    Artesunate

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • P5878

    Potassium Canrenoate

    Aldosterone antagonist.

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • L9600

    LY-2090314

    GSK-3 inhibitor.

    ≥98%
  • P3568

    Pirarubicin

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • V0145

    Valinomycin

    Peptide, neutral ionophore.

    ≥98%
  • D1872

    Des(benzylpyridyl) Atazanavir

    Atazanavir metabolite; HIV protease inhibitor.<...

    ≥98%
  • V2792

    VGX-1027

    TLR4 inhibitor.

    ≥98%
  • A5235

    Amitriptyline Hydrochloride

    FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only