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Cambinol

Cambinol

Product ID C0048
Cas No. 14513-15-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $234.40 In stock
25 mg $972.40 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cambinol is an inhibitor of sirtuins, particularly sirtuin1. Cambinol exhibits anti-inflammatory and anticancer chemotherapeutic activities. In various cell lines, cambinol suppresses MAPK and MEK signaling and inhibits expression of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and IFN-γ. Additionally, cambinol improves survival of animal models of endotoxic shock and septic shock. In vitro, cambinol inhibits proliferation and increases differentiation and senescence in hepatocellular carcinoma cells. In vivo, cambinol inhibits xenograft growth in models of hepatocellular carcinoma and Burkitt’s lymphoma.

Product Info

Cas No.

14513-15-6

Purity

≥98%

Formula

C21H16N2O2S

Formula Wt.

360.43

IUPAC Name

5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one

Synonym

SIRT 1/2 inhibitor IV, SIRT1 Inhibitor II, NSC112546, SIRT2 Inhibitor VI.

Solubility

Soluble in DMSO (≥10 mg/ml), and ethanol (5 mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C0048 MSDS PDF

Info Sheet

C0048 Info Sheet PDF

References

Lugrin J, Ciarlo E, Santos A, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510. PMID: 23499872.

Portmann S, Fahrner R, Lechleiter A, et al. Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Mol Cancer Ther. 2013 Apr;12(4):499-508. PMID: 23339189.

Heltweg B, Gatbonton T, Schuler AD, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77. PMID: 16618762.

Custom Order

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