• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
CHIR-99021

CHIR-99021

Product ID C291342
Cas No. 252917-06-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.00 In stock
25 mg $388.00 In stock
100 mg $1,124.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

CHIR-99021 is a highly potent and specific inhibitor of GSK3 that induces differentiation and facilitates development of hematopoietic stem cells. Addition of agents such as rapamycin or retinoic acid to the treatment of human embryonic stem cells was found to strengthen the function of CHIR-99021.

Product Info

Cas No.

252917-06-9

Purity

≥98%

Formula

C22H18Cl2N8

Formula Wt.

465.34

Chemical Name

CHIR 99021

IUPAC Name

6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile

Synonym

CHIR99021; CT 99021; CT-99021; CT99021

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C291342 MSDS PDF

Info Sheet

C291342 Info Sheet PDF

References

Galat Y, Elcheva I, Dambaeva S, et al. Application of small molecule CHIR99021 leads to the loss of hemangioblast progenitor and increased hematopoiesis of human pluripotent stem cells. Exp Hematol. 2018 Sep;65:38-48. PMID: 29879440.

Laco F, Woo TL, Zhong Q, et al. Unraveling the inconsistencies of cardiac differentiation efficiency induced by the GSK3β inhibitor CHIR99021 in human pluripotent stem cells. Stem Cell Reports. 2018 Jun 5;10(6):1851-1866. PMID: 29706502.

Qiu XX, Liu Y, Zhang YF, et al. Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation form human pluripotent stem cells via reducing p53-dependent apoptosis. J Am Heart Assoc. 2017 Oct 2;6(10). pii:e005295. PMID: 28971953.

Cheng T, Zhai K, Chang Y, et al. CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells. Oncotarget. 2017 Jan 31;8(5):7814-7826. PMID: 27999196.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0777

    ABT-263

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥99%
  • A0833

    Acipimox

    Niacin derivative.

    ≥98%
  • K0652

    Kb NB 142-70

    PKD inhibitor.

    ≥98%
  • P1845

    Pelitinib

    EGFR inhibitor.

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • D1627

    Dehydrocostus Lactone

    Sesquiterpene lactone found in Saussurea.

    ≥98%
  • A046189

    Abexinostat

    Primarily targets HDAC1

    ≥98%
  • S0400

    SB-431542

    ALK4/5/7 (activin-like) inhibitor, TGF-β inhib...

    ≥98%
  • B3320

    Bifonazole

    Imidazole; HMG-CoA reductase, 14-α demethylase...

    ≥98%
  • G0145

    Gallic Acid

    Phenol found in various plant sources, used to ...

    ≥98%
  • T2817

    Theophylline

    Methylxanthine; PDE inhibitor, A1/2 adenosine a...

    ≥98%
  • L0250

    Laminin Peptide SIKVAV

    Laminin-derived hexapeptide.

    ≥98%
  • A2056

    Aflatoxin Q1

    Mycotoxin metabolite

    ≥98%
  • L8262

    Lupinine

    Alkaloid found in species of Loranthus, Calia, ...

    ≥98%
  • B165122

    Bedaquiline

    Bactericidal

    ≥99%
  • R5874

    Rosmarinic Acid

    Caffeic acid ester found in Melissa, Salvia, an...

    ≥98%
  • C9879

    Cytochalasin B

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • G0246

    Galantamine Hydrobromide

    Alkaloid found in Galanthus, Narcissus, Leucoju...

    ≥98%
  • H965142

    Hydrolyzed Fumonisin B1

    Mycotoxin produced by Fusarium fungi that infec...

    ≥99% by ELSD
  • G4596

    Glycidamide

    Epoxide metabolite of acrylamide, induces DNA a...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2026 LKT Laboratories, All Rights Reserved - Products for research use only