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Chloroquine Diphosphate

Chloroquine Diphosphate

Product ID C2950
Cas No. 50-63-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 g $79.70 In stock
50 g $153.00 In stock
100 g $223.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chloroquine is an aminoquinoline antimalarial that is clinically used to treat malaria. Chloroquine’s anti-parasitic activity stems from its ability to bind heme, resulting in disruption of membrane function and cell lysis. Chloroquine also displays antiviral, immunosuppressive, and anticancer activities. Chloroquine inhibits the replication of many viruses and also inhibits production of IL-6 and TNF-α. Additionally, chloroquine improves the efficacy of co-administered chemotherapeutics and suppresses the induction of autophagy in vitro.

Product Info

Cas No.

50-63-5

Purity

≥98%

Formula

C18H26ClN3 • 2H3PO4

Formula Wt.

515.87

Chemical Name

N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4- pentanediamine diphophate

IUPAC Name

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1, 4-diamine;phosphoric acid

Synonym

Chloroquine diphosphate, Arechin, Avloclor, Malaquin, Tresochin

Melting Point

193-195°C & 215-218°C

Solubility

Soluble in water.

Appearance

White or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C2950 MSDS PDF

Info Sheet

C2950 Info Sheet PDF

References

Liang X, Tang J, Liang Y, et al. Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci. 2014 Mar 3;4(1):10. PMID: 24581180.

Hempelmann E. Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors. Parasitol Res. 2007 Mar;100(4):671-6. PMID: 17111179.

Savarino A, Boelaert JR, Cassone A, et al. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis. 2003 Nov;3(11):722-7. PMID: 14592603.

Custom Order

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  • This field is for validation purposes and should be left unchanged.

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