Chloroquine is an aminoquinoline antimalarial that is clinically used to treat malaria. Chloroquine’s anti-parasitic activity stems from its ability to bind heme, resulting in disruption of membrane function and cell lysis. Chloroquine also displays antiviral, immunosuppressive, and anticancer activities. Chloroquine inhibits the replication of many viruses and also inhibits production of IL-6 and TNF-α. Additionally, chloroquine improves the efficacy of co-administered chemotherapeutics and suppresses the induction of autophagy in vitro.