• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
CYT-387

CYT-387

Product ID C9876
Cas No. 1056634-68-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 In stock
5 mg $177.20 In stock
10 mg $278.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

CYT-387 (momelotinib) is an inhibitor of JAK2 currently under investigation as a potential treatment for myeloproliferative neoplasms; it displays anticancer chemotherapeutic activity. In cellular models of multiple myeloma, momelotinib induces G2/M phase cell cycle arrest. In vivo, this compound decreases tumor burden.

Product Info

Cas No.

1056634-68-4

Purity

≥98%

Formula

C23H22N6O2

Formula Wt.

414.46

IUPAC Name

N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide

Synonym

CYT387, CYT11387, Momelotinib

Solubility

DMSO 74 mg/mL (178.54 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow to light orange powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C9876 MSDS PDF

Info Sheet

C9876 Info Sheet PDF

References

Abubaker K, Luwor RB, Zhu H, et al. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. BMC Cancer. 2014 May 6;14:317. PMID: 24886434.

Geyer HL, Tibes R, Mesa RA. JAK2 inhibitors and their impact in myeloproliferative neoplasms. Hematology. 2012 Apr;17 Suppl 1:S129-32. PMID: 22507800.

Monaghan KA, Khong T, Burns CJ, et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia. 2011 Dec;25(12):1891-9. PMID: 21788946.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B3280

    Bis(salicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥98%
  • S0929

    SCH-772984

    ERK1/2 inhibitor.

    ≥97%
  • J3204

    E-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • A484091

    Amcinonide

    Glucocorticoid

    ≥98%
  • T0117

    Benzyl Analog of Taxol

    Benzyl taxol analog; potential microtubule depo...

    ≥95%
  • C4534

    Clindamycin Palmitate Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • L0254

    Lansoprazole

    H+/K+ ATPase inhibitor.

    ≥98%
  • R3221

    3-Formylrifamycin

    Rifamycin derivative, induces pore formation in...

    ≥98%
  • K0023

    K252c

    Staurosporine analog; PKC and PKA inhibitor.

    ≥98%
  • C3477

    Citalopram Hydrobromide

    SERT inhibitor.

    ≥98%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • P7158

    Protopine

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • H1657

    Heparin-binding Peptide

    Peptide, binds heparin.

    ≥95%
  • N1755

    Neomycin Sulfate

    Polycationic aminoglycoside; protein translatio...

    ≥98%
  • B8277

    Butein

    Flavonoid found in Rhus verniciflua and Butea m...

    ≥99%
  • S5753

    Somatostatin-28 (1-14)

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • D1695

    Dexamethasone Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%
  • N1980

    Neuromedin B, pig

    Endogenous bombesin-related peptide, involved i...

    ≥95%
  • D183740

    Desoxypipradrol

    NDRI inhibitor

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only