Description
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
Product Unit Size | Cost | Quantity | Stock |
---|
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
Cas No. | 934660-93-2 |
---|---|
Purity | ≥99% |
Formula | C21H21F3IN3O2 |
Formula Wt. | 531.32 |
IUPAC Name | {3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone |
Synonym | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.
Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.
Macrolide; ET antagonist, proteasome inhibitor....
CDK inhibitor, L-type Ca2+ channel blocker.
Tripeptide, used to tag proteins.
Antioxidant.
Fluorinated aminopropyl carbazole, neuroprotect...
Endogenous amino sugar precursor required for p...
Endogenous peptide neurotransmitter, involved i...
β-adrenergic agonist.
Glucocorticoid
SIRT inhibitor.
NSAID; COX-1/2 inhibitor.
Bisphosphonate.
IMPDH inhibitor.
Echinocandin antifungal
BHA derivative.
Iron chelator.
Form of vitamin C found in various plant and fo...
Peptide, carbonic anhydrase G250 epitope.
Mycotoxin derivative; actin polymerization inhi...
Kavalactone originally found in Piper methystic...