Description
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
| Cas No. | 934660-93-2 |
|---|---|
| Purity | ≥99% |
| Formula | C21H21F3IN3O2 |
| Formula Wt. | 531.32 |
| IUPAC Name | {3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone |
| Synonym | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.
Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.
Found in hawthorn.
Histamine H2 antagonist, GSK-3β inhibitor.
Mast cell destabilizer; potential TRP antagonis...
Benzimidazole; microtubule polymerization inhib...
PAK4 inhibitor.
Flavone found in Teucrium.
Allosteric inhibitor
PKC and PKD activator, carcinogen.
Alkaloid found in species of Loranthus, Calia, ...
Peptide, used to tag proteins for affinity chro...
AChE inhibitor, F0F1-ATP synthase modulator.
Endogenous peptide hormon involved in energy ho...
Non-depolarizing NMJ blocker; nAChR and M2/3 mA...
Impurity of omeprazole
Selective 5-HT6 receptor antagonist
Antimicrobial peptide found in Hyalophora cecro...
Thienylbutyl ITC analog.
Nucleoside (cytidine) analog; DNMT inhibitor, p...
Tamoxifen derivative; potential proteasome inhi...
5-HT2 antagonist, SERT and NET inhibitor, hERG ...