Name: GDC-0973
SKU: G124084
Availability: InStock

Description

GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.

Product Info

Cas No.	934660-93-2
Purity	≥99%
Formula	C₂₁H₂₁F₃IN₃O₂
Formula Wt.	531.32
IUPAC Name	{3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone
Synonym	GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G124084 MSDS PDF
Info Sheet	G124084 Info Sheet PDF

References

Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.

Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.

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GDC-0973

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