Description
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
| Cas No. | 934660-93-2 |
|---|---|
| Purity | ≥99% |
| Formula | C21H21F3IN3O2 |
| Formula Wt. | 531.32 |
| IUPAC Name | {3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone |
| Synonym | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.
Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.
Highly selective inhibitor
Macrolide lactone found in Bugula; TLR4 activat...
Endogenous opioid peptide; μOR agonist.
Induces ER degradation.
Mycotoxin produced by Fusarium; ER agonist.
Nucleoside (thymidine) analog; RT inhibitor.
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Calcium channel blocker.
VEGFR, PDGFR, c-Kit inhibitor.
Inhibitor of Bruton’s tyrosine kinase (BTK).<...
AurKB/C inhibitor.
D2/3 agonist.
Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...
GSK-3β inhibitor.
PLK1 inhibitor.
Triterpene saponin found in species of Panax.
Peptide; fibrinolysis inhibitor.
NSAID; COX inhibitor and HS-releasing agent.
Nicotinamide analog prodrug; fatty acid synthet...
Indole derivative found in Isatis, Calanthe, an...