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J-147

J-147

Product ID J0001
Cas No. 1146963-51-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $58.50 In stock
25 mg $116.80 In stock
100 mg $240.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

J-147 is a phenyl hydrazide that exhibits neuroprotective and cognition enhancing activities. In vitro, this compound decreases neuronal loss, oxidative stress, and glutamate-induced neurotoxicity. J-147 also ameliorates memory impairment in animal models of Alzheimer’s disease.

Product Info

Cas No.

1146963-51-0

Purity

≥98%

Formula

C18H17F3N2O2

Formula Wt.

350.34

IUPAC Name

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide

Synonym

J147, Unii-Z41H3C5BT9

Solubility

100mM in DMSO and ethanol

Appearance

Light yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J0001 MSDS PDF

Info Sheet

J0001 Info Sheet PDF

References

Chen HY, Xu DP, Tan GL, et al. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. J Mol Neurosci. 2015 May 17. [Epub ahead of print]. PMID: 25982925.

Prior M, Dargusch R, Ehren JL, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. PMID: 23673233.

Chiruta C, Zhao Y, Tang F, et al. Metabolism of a potent neuroprotective hydrazide. Bioorg Med Chem. 2013 May 15;21(10):2733-41. PMID: 23582448.

Custom Order

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