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L-Alliin

L-Alliin

Product ID A4444
Cas No. 17795-26-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $202.70 In stock
500 mg $833.50 In stock
1 g $1,342.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

L-Alliin is a cysteine derivative found in Allium; it exhibits anti-inflammatory, neuromodulatory, anti-diabetic, anti-hyperlipidemic, antioxidative, cardioprotective, and anti-angiogenic activities. In adipocytes, L-alliin inhibits LPS-stimulated activation of ERK1/2 and increases in inflammatory signaling. In animal models of myocardial infarction, L-alliin increases activity of superoxide dismutase, glutathione peroxidase, catalase, and glutathione-S-transferase. L-Alliin also activates NMDA-R subunits NR2A and NR2B. In diabetic rats, this compound decreases levels of LDL, VLDL, glucose, triglycerides, total cholesterol, and total lipids. Additionally, L-alliin inhibits VEGF-induced angiogenesis and FGF2 and VEGF secretion in fibrosarcoma cells.

Product Info

Cas No.

17795-26-5

Purity

≥98%

Formula

C6H11NO3S

Formula Wt.

177.22

Chemical Name

3-[(S)-2-Propenylsulfinyl]-L-alanine

IUPAC Name

(2R)-2-amino-3-prop-2-enylsulfinylpropanoic acid

Synonym

R,S-Allyl-L-cysteine sulfoxide

Melting Point

164-166°C

Solubility

Soluble in water. Practically insoluble in ethanol, chloroform, acetone, ether, and benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4444 MSDS PDF

Info Sheet

A4444 Info Sheet PDF

References

Ieong Tou W, Chang SS, Wu D, et al. Molecular level activation insights from a NR2A/NR2B agonist. J Biomol Struct Dyn. 2014;32(5):683-93. PMID: 23600691.

Quintero-Fabián S, Ortuño-Sahagún D, Vázquez-Carrera M, et al. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators Inflamm. 2013;2013:381815. PMID: 24453416.

Nasim SA, Dhir B, Kapoor R, et al. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats. Pharm Biol. 2011 Apr;49(4):416-21. PMID: 21391887.

Sangeetha T, Darlin Quine S. Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol induced cardiotoxicity in male Wistar rats: a histopathological study. Mol Cell Biochem. 2009 Aug;328(1-2):1-8. PMID: 19262997.

Mousa AS, Mousa SA. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer. 2005;53(1):104-10. PMID: 16351512.

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