• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Lacidipine

Lacidipine

Product ID L0108
Cas No. 103890-78-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $73.50 In stock
50 mg $236.30 In stock
250 mg $288.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lacidipine is a third-generation dihydropyridine calcium channel blocker that has a demonstrated effectiveness against hypertension. It has been shown to have a preventative effect on myocardial hypertrophy and remodeling in male spontaneously hypertensive rats. In patient-derived Gaucher’s disease fibroblasts, lacidipine has been found to enhance folding, trafficking, and activity of mutated glucocerebrosidase variants. It has been observed to function as a proteostasis regulator and to rescue L444P GC folding with considerably high efficiency by upregulating BiP expression. In addition to blocking L-type Ca2+ channels on the plasma membrane, it has been found to block Ryanodine receptors on the endoplasmic reticulum membrane. It has been shown to activate each of the three arms of the unfolded protein response signal transduction cascade and yet to prevent apoptosis induction, thereby promoting cell survival. Furthermore, lacidipine has been shown to possess antibacterial activity against various organisms, including Vibrio cholerae 569B cells in experimental rabbit ileal loops.

Product Info

Cas No.

103890-78-4

Purity

≥98%

Formula

C26H33NO6

Formula Wt.

455.55

Chemical Name

diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate

IUPAC Name

Diethyl 2,6-dimethyl-4-(2-{(1E)-3-[(2-methyl-2-propanyl)oxy]-3-oxo-1-propen-1-yl}phenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Synonym

Lacipil, Motens, GR-43659X

Solubility

DMSO 91 mg/mL; Water <1 mg/mL

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

L0108 MSDS PDF

Info Sheet

L0108 Info Sheet PDF

References

Ge Y, Li G, Liu B, et al. The Protective Effect of Lacidipine on myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats. Evid Based Complement Alternat Med. 2015; 2015: 945076. PMID: 25688281.

Wang F, Chou A, Segatori L. Lacidipine Remodels Protein Folding and Ca2+ Homeostasis in Gaucher’s Disease Fibroblasts: A Mechanism to Rescue Mutant Glucocerebrosidase. Chem Biol. 2011 Jun 24; 18(6):766-76. PMID: 21700212.

Wang F, Segatori L. Remodeling the Proteostasis Network to Rescue Glucocerebrosidase Variants by Inhibiting ER-Associated Degradation and Enhancing ER Folding. PLoS One. 2013 Apr 19; 8(4):e61418. PMID: 23620750.

Dasgupta A, Dastidar S, Antibacterial & antitoxic effects of the cardiovascular drug lacidipine in an animal model. Indian J Med Res. 2012 Jun; 135(6): 913-916. PMID: 22825612.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1644

    Meloxicam

    NSAID; COX-2 inhibitor.

    ≥98%
  • L1782

    Levodopa

    Endogenous catecholamine precursor, also found ...

    ≥98%
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • S5753

    Somatostatin-28 (1-14)

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • V3455

    Vinpocetine

    Targets nuclear factor kappa B activation.

    ≥98%
  • L0211

    Lactulose

    Synthetic non-digestible disaccharide.

    ≥99%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.  
    ≥98%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • C0140

    Calcitonin, eel

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • C9662

    Cyproterone Acetate

    Steroid; AR antagonist.

    ≥98%
  • P2303

    Phallacidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥98%
  • R0250

    Ranatensin

    Peptide found in amphibians.

    ≥98%
  • C3477

    Citalopram Hydrobromide

    SERT inhibitor.

    ≥98%
  • P7358

    Psoralen

    Furanocoumarin found in Psoralea coryfolia, DNA...

    ≥98%
  • C2965

    Chromium Picolinate

    Used to prevent chromium deficiency and to decr...

    ≥98%
  • D5607

    Dobutamine Hydrochloride

    β1-adrenergic agonist, β2- and α1-adrenergic...

    ≥98%
  • C9609

    Cyclophosphamide Monohydrate

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • T9970

    Tyrphostin AG1295

    PDGFR inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only